Results 41 to 50 of about 7,886,175 (305)
Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Nature Communications, 2017 Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor ...
Justin J. -L. Wong +11 more
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Stem cell therapy and the retina [PDF]
Eye, 2007 Retinal degeneration culminating in photoreceptor loss is the leading cause of untreatable blindness in the developed world. In this review, we consider how photoreceptors might be replaced by transplantation and how stem cells might be optimised for use as donor cells in future clinical strategies for retinal repair. We discuss the current advances in
MacLaren, R. E., Pearson, R. A.
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Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
Journal of Hematology & Oncology, 2017 Methylation of N6 adenosine (m6A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing.
Chau-To Kwok +3 more
doaj +1 more source
Stem Cell Therapy for the Heart [PDF]
Congestive Heart Failure, 2004 Cellular cardiomyoplasty is an expanding field of research that involves numerous types of immature cells administered via several modes of delivery. The purpose of this review is to investigate the benefits of different types of cells used in stem cell research as well as the most efficient mode of delivery. The authors also present data showing that
Loren E, Wold +6 more
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The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse [PDF]
, 2011 A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients.
Merlos-Suárez, Anna +45 more
core +1 more source
The lady vanishes: what's missing from the stem cell debate [PDF]
, 2006 Most opponents of somatic cell nuclear transfer and embryonic stem cell technologies base their arguments on the twin assertions that the embryo is either a human being or a potential human being, and that it is wrong to destroy a human being or ...
Dickenson, Donna, Donna L. Dickenson
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Ethical and Regulatory Challenges with Autologous Adult Stem Cells:A Comparative Review of International Regulations [PDF]
, 2015 Cell and tissue-based products, such as autologous adult stem cells, are being prescribed by physicians across the world for diseases and illnesses that they have neither been approved for or been demonstrated as safe and effective in formal clinical ...
Lysaght, T +9 more
core +1 more source
Stem cell therapy independent of stemness
World Journal of Stem Cells, 2012 Mesenchymal stem cell (MSC) therapy is entering a new era shifting the focus from initial feasibility study to optimization of therapeutic efficacy. However, how MSC therapy facilitates tissue regeneration remains incompletely characterized. Consistent with the emerging notion that secretion of multiple growth factors/cytokines (trophic factors) by MSC
openaire +2 more sources