Results 1 to 10 of about 12,167,296 (369)
Stem cells, cancer, and cancer stem cells [PDF]
Nature, 2001Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
T. Reya+3 more
semanticscholar +5 more sources
Neuro-Oncology, 2010
Stem cells offer the potential of new therapies for previously untreatable diseases. This session focuses on different aspects of stem cells from embryonic stem cells to adult stem cells and the biology and therapeutic impact of cancer stem cells.
L. Cheng+201 more
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Stem cells offer the potential of new therapies for previously untreatable diseases. This session focuses on different aspects of stem cells from embryonic stem cells to adult stem cells and the biology and therapeutic impact of cancer stem cells.
L. Cheng+201 more
+7 more sources
Cells, Stem Cells, and Cancer Stem Cells [PDF]
Seminars in Reproductive Medicine, 2013The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Carlos Simón+1 more
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Mechanically-driven Stem Cell Separation in Tissues caused by Proliferating Daughter Cells [PDF]
SciPost Phys. 16, 097 (2024), 2023The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be tightly regulated to avoid pathologies, such as tumor growth, the regulatory mechanisms, both cell-intrinsic and collective, which ensure tissue steady-state are still poorly ...
arxiv +1 more source
Regulation of stem cell dynamics through volume exclusion [PDF]
Garc\'ia-Tejera R, SchumacherL, Grima R. 2022 Regulation of stem cell dynamics through volume exclusion. Proc.R.Soc.A478: 20220376, 2022Maintenance and regeneration of adult tissues rely on the self-renewal of stem cells. Regeneration without over-proliferation requires precise regulation of the stem cell proliferation and differentiation rates. The nature of such regulatory mechanisms in different tissues, and how to incorporate them in models of stem cell population dynamics, is ...
arxiv +1 more source
Stem Cells and Stem Cell Therapy
MedEdPORTAL, 2013Abstract This team-based learning (TBL) exercise presents hematopoietic malignancies of myeloid origin and invites users to consider appropriate methods of treatment utilizing stem cell therapy. The 100-minute session is structured in traditional TBL format, and all components—including the learning objectives, reading assignments, individual Readiness
Adam Gromley, Zeynep Gromley
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PTEN, Stem Cells, and Cancer Stem Cells [PDF]
Journal of Biological Chemistry, 2009Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with ...
Hong Wu, Reginald Hill
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Stem Cells and Cancer Stem Cells [PDF]
, 2011The different organs in human organism are constituted by tissues with mature and specialized cells and its specific stem cells. Stem cells represent only a minuscule fraction of cells that constitute each tissue but they are the only cells with self-renewal capacity. The organ-specific stem cells have specific properties that maintain tissue integrity
Alfredo Ribeiro-Silva+2 more
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Prostate Stem Cells and Cancer Stem Cells [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as
Michael M. Shen, Jia J. Li
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Stem cell population asymmetry can reduce rate of replicative aging [PDF]
Journal of Theoretical Biology 331 (2013) 19-27, 2012Cycling tissues such as the intestinal epithelium, germ line, and hair follicles, require a constant flux of differentiated cells. These tissues are maintained by a population of stem cells, which generate differentiated progenies and self-renew. Asymmetric division of each stem cell into one stem cell and one differentiated cell can accomplish both ...
arxiv +1 more source