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Plastic and Reconstructive Surgery, 2010 Stem cells are self-renewing cells capable of differentiating into multiple cell lines and are classified according to their origin and their ability to differentiate. Enormous potential exists in use of stem cells for regenerative medicine. To produce effective stem cell-based treatments for a range of diseases, an improved understanding of stem cell ...
Björn, Behr +4 more
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Cells, Stem Cells, and Cancer Stem Cells [PDF]
Seminars in Reproductive Medicine, 2013 The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Aguilar-Gallardo, C, Simon, C
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Stem cells, cancer, and cancer stem cells [PDF]
Nature, 2001 Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Reya, T. +3 more
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Stem cells supporting other stem cells [PDF]
Frontiers in Genetics, 2013 Adult stem cell therapies are increasingly prevalent for the treatment of damaged or diseased tissues, but most of the improvements observed to date are attributed to the ability of stem cells to produce paracrine factors that have a trophic effect on existing tissue cells, improving their functional capacity.
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PTEN, Stem Cells, and Cancer Stem Cells [PDF]
Journal of Biological Chemistry, 2009 Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with ...
Reginald, Hill, Hong, Wu
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Prostate Stem Cells and Cancer Stem Cells [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as
Jia J, Li, Michael M, Shen
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Embryonic stem cell-derived hematopoietic stem cells [PDF]
Proceedings of the National Academy of Sciences, 2005 Despite two decades of studies documenting thein vitroblood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exploited theCdx-Hoxpathway, a genetic program important for blood development, to enhance the ...
Yuan, Wang +4 more
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Development, 2004 Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow ...
BIANCO, Paolo, P.G. Robey
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Stem Cell Niches: Famished Paneth Cells, Gluttonous Stem Cells [PDF]
Current Biology, 2012 Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.
Kim, Tae-Hee, Shivdasani, Ramesh A.
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Current Oncology, 2022 Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups.
Gaganvir Parmar +9 more
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