Results 31 to 40 of about 12,311,631 (363)
When is a stem cell really a stem cell? [PDF]
Bone Marrow Transplantation, 2003 While bone marrow transplantation has long been established as an effective approach to the clinical management of a variety of malignant and nonmalignant diseases, the future application of pluripotent stem cells in transplant settings promises to deliver this therapy to a much broader range of indications.
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Differentiation of multipotent vascular stem cells contributes to vascular diseases. [PDF]
, 2012 It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases.
Chu, Julia S +7 more
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Current Biology, 2003 AbstractBritain is publicly and privately backing stem-cell research but worries continue about the legal framework scientists face in undergoing such work ...
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In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]
, 2014 Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique +13 more
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Using single-cell entropy to describe the dynamics of reprogramming and differentiation of induced pluripotent stem cells [PDF]
, 2020 Induced pluripotent stem cells (iPSCs) provide a great model to study the process of reprogramming and differentiation of stem cells. Single-cell RNA sequencing (scRNA-seq) enables us to investigate the reprogramming process at single-cell level. Here, we introduce single-cell entropy (scEntropy) as a macroscopic variable to quantify the cellular ...
arxiv +1 more source
Development, 2004 Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow ...
BIANCO, Paolo, P.G. Robey
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First steps to define murine amniotic fluid stem cell microenvironment [PDF]
, 2016 Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix ...
Bertin, Enrica +11 more
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Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. [PDF]
, 2017 Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient ...
A Ootani +86 more
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The individuality of stem cells [PDF]
BMC Biology, 2011 Lander BMC Biology 2011, 9:40 http://www.biomedcentral.com/1741-7007/9/40 CO M M E N T Open Access The individuality of stem cells Arthur D Lander* When a group of immigrants moves into a community in large numbers, so much attention is usually focused on how they are different – in language, customs, appearance, and so on – from everyone else, that ...
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Dynamics of cell-type transition mediated by epigenetic modifications [PDF]
arXiv, 2023 Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. The Waddington landscape posits that gene circuits in a cell form a potential landscape of different cell types, wherein cells follow attractors of the probability landscape to develop into distinct cell types.
arxiv