Results 51 to 60 of about 2,109,940 (213)
Stem Cells: Specifying Stem-Cell Niches in the Worm [PDF]
Recent work has shown that components of the Wnt signaling pathway directly activate a homeodomain transcription factor so as to specify the cell fate that provides niche function to germline stem cells in the nematode Caenorhabditis elegans.
Samantha Van Hoffelen, Michael A. Herman
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Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. [PDF]
Intestinal stem cells (ISCs) maintain the midgut epithelium in Drosophila melanogaster Proper cellular turnover and tissue function rely on tightly regulated rates of ISC division and appropriate differentiation of daughter cells.
Abramov+68 more
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Background Osteoarthritis is a prevalent chronic disease that impacts quality of life and imposes a heavy economic burden. Despite this there is no confirmed treatment that could prevent progressive destruction of osteoarthritic joints.
Bora Bright+3 more
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Isolation of Female Germline Stem Cells from Mouse and Human Ovaries by Differential Adhesion
Spermatogonial stem cell (SSC) counterparts known as female germline stem cells (fGSCs) were found in the mammalian ovary in 2004. Although the existence of fGSCs in the mammalian postnatal ovary is still under controversy, fGSC discovery encourages ...
Maryam Saber+2 more
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Limbal stem cell transplantation: clinical results, limits, and perspectives [PDF]
Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium.
Bruscolini, Alice+3 more
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MicroRNAs, stem cells and cancer stem cells
This review discusses the various regulatory characteristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells.
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Method to Convert Stem Cells into Cancer Stem Cells [PDF]
The cancer stem cell (CSC) hypothesis suggests that tumors are sustained exclusively by a small population of the cells with stem cell properties. CSCs have been identified in most tumors and are responsible for the initiation, recurrence, and resistance of different cancers.
Said M. Afify+10 more
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Hematopoietic stem cells are responsible for life-long blood cell production and are highly sensitive to exogenous stresses. The effects of low doses of ionizing radiations on radiosensitive tissues such as the hematopoietic tissue are still unknown ...
Elia Henry+9 more
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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A.+11 more
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SummaryBritain's support for human-animal stem cell research seems to be faltering. Nigel Williams reports.
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