Results 91 to 100 of about 1,076,552 (304)

A large-scale study of academic specialization and sex effects on Corsi block performance

open access: yesFrontiers in Education
This study aimed to investigate the relationship between sex, educational specialization (science, technology, engineering, and mathematics (STEM) vs. non-STEM), and performance on the Corsi block-tapping task (CBT).
Sergey Malykh   +4 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

STEM AND STEAM EDUCATION IN 1st DECADE: A BIBLIOMETRIC ANALYSIS (2014-2025)

open access: yesJurnal Magister Pendidikan Matematika
STEM and STEAM education has become a strategic learning approach in addressing global challenges in the Industrial Revolution 4.0 and Society 5.0 era, focusing on developing 21st-century skills, such as creativity, critical thinking, problem-solving and
Pieter Zakarias Tupamahu   +3 more
doaj   +1 more source

An Investigation into the Challenges Facing Administration of STEM Education in Gwagwalada Universal Basic Education Junior Secondary Schools in FCT, Nigeria

open access: yesInternational Journal of Research in STEM Education, 2020
This study aimed to investigate the challenges facing the administration of STEM Education in Gwgwalada junior secondary schools of FCT, Nigeria. The study employed a descriptive survey design. The instruments used for data collection were questionnaires
Ogunode Niyi Jacob
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Integrating STEM and Mathematical Modeling in Middle School: An Investigation of Students’ Motivation, Attitudes, and Modeling Competence

open access: yesYaşadıkça Eğitim
The purpose of this study is to investigate the effects of integrating STEM and an interdisciplinary modeling-oriented environment (IMOE) in middle school on students’ modeling competence, motivation, and attitudes toward STEM learning.
Nihal Demir, Mustafa Gök
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

STEM education [Editorial] [PDF]

open access: yesIEEE Instrumentation & Measurement Magazine, 2018
Science-Technology-Engineering-Mathematics... Children from 2 to 99 love it! Even without realizing it. A lot of children hate mathematics, but they do not realize that they are using it all of the time when they are flying a drone, remotely operating a toy, using their cellphones, playing games on game consoles...
openaire   +1 more source

Know Your Funders: A Guide to STEM Funding for Afterschool [PDF]

open access: yes, 2012
The need for competency in science, technology, engineering and math (STEM) skills is not only increasingly important for success in the workforce but also to navigate the modern world and to make decisions that will inform public policy.

core  

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