Results 81 to 90 of about 282,779 (307)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Addressing the need to facilitate undergraduate research experiences for community college transfer students in science

Journal of Microbiology & Biology Education
Community college transfer students face numerous challenges, including gaining access to undergraduate research experiences. In this Perspectives piece, we articulate the benefits of undergraduate research experiences for community college transfer ...
Emma C. Goodwin, Katelyn M. Cooper, Logan E. Gin, Sara E. Brownell   +3 more
doaj   +1 more source

Blood: Education for stem cells

Nature, 2017
Haematopoietic stem cells give rise to all lineages of blood cell, and their production $\textit{in vitro}$ has been a long-sought goal of stem-cell biology. Two groups now achieve this feat through different means.
Guibentif, C, Göttgens, B
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Changes in Teaching Efficacy Beliefs among Elementary Preservice Teachers from a STEM-focused Program: Case Study Analysis

Journal of Interdisciplinary Teacher Leadership, 2018
Four case studies of preservice teachers enrolled in a STEM-focused elementary teacher preparation program are used to document changes in mathematics and science teaching efficacy over the course of one academic year.
Margareta Maria Thomson, Daniell DiFrancesca, Sarah Carrier, Carrie Lee, Temple A. Walkowiak   +4 more
doaj   +1 more source

Pre-Service Science Teachers’ Views of the Nature of STEM

Science Education International, 2020
Science, technology, engineering, and mathematics (STEM) education plays an important role in teaching and learning for the twenty-first century. Science teacher education is making great efforts to prepare STEM teachers for modern classroom practice and
Chatree Faikhamta
doaj   +1 more source

Perceptions of Teachers towards the STEM Education and the Constructivist Education Approach: Is the Constructivist Education Approach Preparatory to the STEM Education? [PDF]

Universal Journal of Educational Research, 2018
The main purpose of this study is to identify the perceptions of the teachers towards the stem education and the constructivist education approach. The study group of the research consists of 40 primary school teachers, 30 mathematics teachers, 20 science teachers and 15 information technologies teachers, who serve in the city center of Siirt and ...
Akran, Sevda Koç, Aşiroğlu, Sevim
openaire   +3 more sources

Mentorías 3.0 Embarazo en STEM Éxito asegurado en tu formación STEM

, 2022
En el contexto del proyecto W-STEM ERASMUS + Capacity-building in Higher Education European Project (Ref. 598923-EPP-1-2018-1-ES-EPPKA2-CBHE-JP) se ha celebrado la Conferencia Internacional W-STEM Chile los días 19 y 20 de abril de 2022 de forma ...
Grupo de estudiantes mentoras W-STEM
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source