Results 91 to 100 of about 8,869,470 (264)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Gender differences in high school students’ interest in STEM careers: A multi-group comparison based on structural equation model

, 2023
Background Females are underrepresented in Science, Technology, Engineering, and Mathematics (STEM) fields all over the world. To encourage more girls to choose STEM majors and careers, it is critical to increase their interest in STEM careers.
Wang, Ning, Zhuo, Xiaohong, Xiang, Jiong, Tan, Aik-Ling, Liu, Ke, Zeng, Feng   +5 more
core   +1 more source

STEM-based Artificial Intelligence Learning in General Education for Non-Engineering Undergraduate Students

Educational Technology & Society, 2021
This article describes STEM education with artificial intelligence (AI) learning, particularly for non-engineering undergraduate students. In the designed three-week learning activities, students were encouraged to put their ideas about AI into practice ...
Chun-Hung Lin, Chih-Chang Yu, Po-Kang Shih, Leon Yufeng Wu   +3 more
doaj  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A Systematic Literature Review of Integrated STEM Education: Uncovering Consensus and Diversity in Principles and Characteristics

Integrated STEM education is increasingly present in classrooms and in educational research, as it is proposed as a possible strategy to improve the problems of students’ lack of interest in scientific–technological disciplines. However, this
Kristina Zuza, Jenaro Guisasola, Ane Portillo-Blanco, Mieke De Cock, Hanne Deprez   +4 more
core   +1 more source

Conceiving Socioscientific Issues in STEM Lessons from Science Education Research and Practice

, 2021
This paper aims to elicit the different conceptions of Socioscientific Issues (SSI) in formal, non-tertiary STEM lessons. An examination of recent publications in the field of science education was conducted to elicit the most common conceptions of SSI ...
Mario Barajas, Silvia Alcaraz-Dominguez
core   +1 more source

The Role of Education and Science in the Competitiveness of Russian Regions

Высшее образование в России
The relevance of this study is determined by the need to identify factors that define the role of education and science in ensuring the socio-economic development and competitiveness of Russian regions.
A. V. Shkalenko, Denis V. Naumov, E. I. Voevodina   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Students’ Perceptions of STEM: The Role of Demographic Variables and Socio-economic Status

Journal of Educational, Cultural and Psychological Studies
Students’ diminishing interest in science, technology, engineering and mathematics (STEM) courses and lack of qualified graduates in STEM fields continue to be an issuein the developing countries.
Saras Krishnan, Enriqueta D. Reston
doaj   +1 more source