Results 71 to 80 of about 1,084,434 (304)

Addressing the need to facilitate undergraduate research experiences for community college transfer students in science

Journal of Microbiology & Biology Education
Community college transfer students face numerous challenges, including gaining access to undergraduate research experiences. In this Perspectives piece, we articulate the benefits of undergraduate research experiences for community college transfer ...
Emma C. Goodwin, Katelyn M. Cooper, Logan E. Gin, Sara E. Brownell   +3 more
doaj   +1 more source

Changes in Teaching Efficacy Beliefs among Elementary Preservice Teachers from a STEM-focused Program: Case Study Analysis

Journal of Interdisciplinary Teacher Leadership, 2018
Four case studies of preservice teachers enrolled in a STEM-focused elementary teacher preparation program are used to document changes in mathematics and science teaching efficacy over the course of one academic year.
Margareta Maria Thomson, Daniell DiFrancesca, Sarah Carrier, Carrie Lee, Temple A. Walkowiak   +4 more
doaj   +1 more source

Pre-Service Science Teachers’ Views of the Nature of STEM

Science Education International, 2020
Science, technology, engineering, and mathematics (STEM) education plays an important role in teaching and learning for the twenty-first century. Science teacher education is making great efforts to prepare STEM teachers for modern classroom practice and
Chatree Faikhamta
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Secondary school-university partnerships foster STEMM interest and self-agency in rural students

Frontiers in Education
IntroductionRural STEMM education faces significant challenges, including limited access to high-quality STEMM experiences and resources. University-K12 partnerships can address these challenges by providing opportunities for students and teachers to ...
Seema Rivera, Kathleen Kavanagh, Jan DeWaters, Mike Ramsdell, Leigha Burkhalter, Lennart Johns, Nicole Taylor, Megan Smith, Lisa Beldock   +8 more
doaj   +1 more source

The Practices of Play and Informal Learning in the miniGEMS STEAM Camp [PDF]

, 2019
Science, Technology, Engineering, and Mathematics (STEM) play an important role in the educational reform and global economy. However, STEM education lacks the hands-on laboratory in the formal middle school and high school curricula.
Frye, Michael, Nair, Sreerenjini, Wang, Chaoyi   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Per a què estem a STEM? Un intent de definir l’alfabetització STEM per a tothom i amb valors. [PDF]

, 2017
L’educació STEM és una proposta emergent sobre la que se’n parla molt darrerament. Entre els investigadors/es, docents, educadors/es o  dissenyadors/es en educació STEM no hi ha, però, gaire consens més enllà de reconèixer la necessitat d’incidir en ...
Couso, Digna
core   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source