Results 31 to 40 of about 236,518 (260)

Examining students’ computational thinking skills in enhanced-technology mathematics lessons: the effects of gender and grade levels

Discover Education
Computational thinking (CT) has been argued as an essential skill for all students, critical to surviving in the 21st-century era and navigating through a more digital world. Understanding the impact of variables such as gender and age on the development
Wahid Yunianto, Theodosia Prodromou, Zsolt Lavicza, Barbara Sabitzer   +3 more
doaj   +1 more source

Progress or prejudice? Medical school admissions committee members exhibit nuanced responses to applicants revealing bipolar disorder on applications

Advances in Physiology Education
Mental health conditions can be highly relevant to a student’s academic journey, given the challenges, and sometimes strengths, they can provide. However, medical school applicants may be unsure about whether to reveal mental health conditions in their ...
Baylee A. Edwards, Corinne Mitra, Hailey Bunch, Anna E. Abraham, Katelyn M. Cooper, Sara E. Brownell   +5 more
doaj   +1 more source

STEM education through PhET simulations: An effort to enhance students’ critical thinking skills

Jurnal Ilmiah Pendidikan Fisika Al-Biruni, 2022
One of the primary purposes of physics education is to help students develop critical thinking abilities to solve everyday situations. The purpose of this research is to investigate the impact of STEM education using PhET simulation on students' critical
Khaeruddin Khaeruddin, Hartono Bancong
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Short-term stress preconditioning activates sympathetic innervation in the testes to mitigate testicular ischemia-reperfusion injury

Journal of Neuroinflammation
Testicular tissues are highly vulnerable to oxidative stress and external insults due to their unique physiological microenvironment; thus, developing protective interventions is critical.
Liyong Liu, Ruiming Xu, Heshe Li, Yuanchen Ma, Yue Shu, Hongjie Liang, Tao Wang, Jiang Hao, Weiqiang Li, Andy Peng Xiang, Mei Hua Jiang, Weijun Huang   +11 more
doaj   +1 more source

Mathematics teachers’ cognitive engagement strategies: an ICAP-TS analysis across age, experience, and gender

Cogent Education
Recognizing the vital role that teachers play in shaping student engagement through the use of technology, this study investigates the intentions of mathematics teachers to employ technology-driven cognitive engagement strategies. Specifically, the study
Robert Weinhandl, Branko Anđić, Cornelia S. Große, Selina Baldinger, Jonas Mayrhofer, Valentina Bleckenwegner, Viktoria Riegler   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source