Results 151 to 160 of about 106,531 (314)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann +11 morewiley +1 more sourceSpatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours +11 morewiley +1 more sourceInhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli +10 morewiley +1 more sourceCancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia +15 morewiley +1 more sourceEpigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 morewiley +1 more sourcePANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang +4 morewiley +1 more sourceSomatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan +6 morewiley +1 more sourceProfiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic +10 morewiley +1 more sourceExtracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon +9 morewiley +1 more sourceStem Cells [PDF]
Neuro-Oncology, 2010 L. Cheng, Z. Huang, W. Zhou, Q. Wu, J. Rich, S. Bao, P. Baxter, H. Mao, X. Zhao, Z. Liu, Y. Huang, H. Voicu, S. Gurusiddappa, J. M. Su, L. Perlaky, R. Dauser, H.-c. E. Leung, K. M. Muraszko, J. A. Heth, X. Fan, C. C. Lau, T.-K. Man, M. Chintagumpala, X.-N. Li, P. Clark, M. Zorniak, Y. Cho, X. Zhang, D. Walden, E. Shusta, J. Kuo, S. Sengupta, S. Goel-Bhattacharya, S. Kulkarni, B. Cochran, C. Cusulin, A. Luchman, S. Weiss, M. Wu, N. Fernandez, S. Agnihotri, R. Diaz, J. Rutka, M. Bredel, J. Karamchandani, S. Das, B. Day, B. Stringer, F. Al-Ejeh, M. Ting, J. Wilson, K. Ensbey, P. Jamieson, Z. Bruce, Y. C. Lim, C. Offenhauser, S. Charmsaz, L. Cooper, J. Ellacott, A. Harding, J. Lickliter, P. Inglis, B. Reynolds, D. Walker, M. Lackmann, A. Boyd, A. Berezovsky, L. Poisson, L. Hasselbach, S. Irtenkauf, A. Transou, T. Mikkelsen, A. C. deCarvalho, D. Emlet, C. Del Vecchio, P. Gupta, G. Li, S. Skirboll, A. Wong, J. Figueroa, T. Shahar, A. Hossain, F. Lang, S. Fouse, J. Nakamura, C. D. James, S. Chang, J. Costello, J. M. Frerich, S. Rahimpour, Z. Zhuang, J. D. Heiss, A. Golebiewska, D. Stieber, L. Evers, E. Lenkiewicz, N. H. C. Brons, N. Nicot, A. Oudin, S. Bougnaud, F. Hertel, R. Bjerkvig, M. Barrett, L. Vallar, S. P. Niclou, X. Hao, J. Rahn, E. Ujack, X. Lun, G. Cairncross, S. Weiss, D. Senger, S. Robbins, J. Harness, R. Lerner, Y. Ihara, R. Santos, J. D. L. Torre, A. Lu, T. Ozawa, T. Nicolaides, D. James, C. Petritsch, D. Higgins, M. Schroeder, B. Ball, B. Milligan, F. Meyer, J. Sarkaria, J. Henley, W. Flavahan, Q. Wu, M. Hitomi, N. Rahim, Y. Kim, A. Sloan, R. Weil, I. Nakano, J. Sarkaria, B. Stringer, M. Li, J. Lathia, J. Rich, A. Hjelmeland, M. Kaluzova, S. Platt, M. Kent, A. Bouras, R. Machaidze, C. Hadjipanayis, S.-G. Kang, S.-H. Kim, Y.-M. Huh, E.-H. Kim, E.-K. Park, J. H. Chang, S. H. Kim, Y. K. Hong, D. S. Kim, S.-J. Lee, E. H. Kim, S. G. Kang, M. Hitomi, L. Deleyrolle, M. Sinyuk, M. Li, W. Goan, B. Otvos, M. Rohaus, M. Oli, V. Vedam-Mai, D. Schonberg, Q. Wu, J. Rich, B. Reynolds, J. Lathia, S.-T. Lee, K. Chu, S.-H. Kim, S. K. Lee, M. Kim, J.-K. Roh, R. Lerner, A. Griveau, Y. Ihara, B. Reichholf, M. McMahon, D. Rowitch, D. James, C. Petritsch, R. Nitta, S. Mitra, M. Agarwal, T. Bui, G. Li, J. Lin, C. Adamson, J. Martinez-Quintanilla, S.-H. Choi, D. Bhere, A. Shavkunov, R. Spelat +201 moreopenaire +3 more sources
