Results 81 to 90 of about 320,127 (267)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Efeito do ataque de Alabama argillacea no crescimento vegetativo e sua relação com a fenologia do algodoeiro Effect of Alabama argillacea attack on vegetative growth and its relationship with cotton phenology

Pesquisa Agropecuária Brasileira, 2001
O objetivo deste trabalho foi estudar o efeito do ataque do curuquerê (Alabama argillacea Hübner, 1818), no desenvolvimento vegetativo do algodoeiro e sua relação com a fenologia da planta.
Ednaldo da Silva Quirino, José Janduí Soares   +1 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Timescales distribution and reactive structures in MILD reactors for different energy carriers

Results in Engineering
Moderate or Intense Low-oxygen Dilution (MILD) combustion processes are purported to be fuel-flexible, thus offering a real opportunity to use a large palette of fuels.
Giovanni Battista Ariemma, Giancarlo Sorrentino, Pino Sabia, Alessandro Parente, Raffaele Ragucci, Mara de Joannon   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Descripción anatómica vegetativa de dos especies de Nymphoides (Menyanthaceae) Vegetative anatomy of two Nymphoides species (Menyanthaceae)

Revista Mexicana de Biodiversidad, 2006
En México crecen dos especies de Nymphoides, N. indica y N. fallax. El conocimiento de la anatomía del género es incompleto y N. fallax no se ha tratado.
Mahinda Martínez, Maricela Gómez Sánchez   +1 more
doaj  

Assessment of Charge Dilution Strategies to Reduce Fuel Consumption in Natural Gas-Fuelled Heavy-Duty Spark Ignition Engines

Energies
The need to decarbonize the road transport sector is driving the evaluation of alternative solutions. From a long-term perspective, biomethane and e-methane are particularly attractive as green energy carriers and a part of the solutions for the ...
Davide Di Domenico, Pierpaolo Napolitano, Dario Di Maio, Carlo Beatrice   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Hybrid Energy System Based on Externally Fired Micro Gas Turbines, Waste Heat Recovery and Gasification Systems: An Energetic and Exergetic Performance Analysis

Energies
The opportunities related to the adoption of synthetic gaseous fuels derived from solid biomass are limited by the issues caused by the peculiarities of the syngas. The aim of this paper is to analyze several possible layouts of hybrid energy systems, in
Fabrizio Reale, Patrizio Massoli
doaj   +1 more source