Results 91 to 100 of about 5,999,373 (245)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Review on Multi-Step Attack Detection

IEEE Access
Multi-step Attacks (MSAs) pose a significant cybersecurity threat, aiming at valuable assets and essential infrastructure across diverse sectors. This study offers an in-depth investigation of methodologies for multi-step attack detection, prevention ...
Syed Usman Shaukat, Saad Khan, Simon Parkinson   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Spørsmål til Skole-Norge: Tabellrapport fra Utdanningsdirektoratets spørreundersøkelser blant skoler og skoleeiere våren 2009 [PDF]

, 2009
Norsk Institutt for studier av innovasjon, forskning og utdanning (NIFU STEP) har inngått en treårig rammeavtale med Utdanningsdirektoratet om å gjennomføre halvårlige spørreundersøkelser rettet mot skoler og skoleeiere.
Evensen, Miriam, Hovdhaugen, Elisabeth, Vibe, Nils   +2 more
core  

Step‐by‐step image enhancement method for PTZ‐camera based crack detection in expressways

Electronics Letters
Cracks on highway pavement surfaces are among the most critical problems affecting expressway maintenance. A pan/tilt/zoom (PTZ) camera‐based crack detection method was proposed, owing to the intelligent traffic system (ITS) development of an expressway ...
Zhiqiang Xia, Chunyan Shao, Xuezhi Feng, Huaiqiang Wang   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Organisering, styring og ledelse ved Høgskolen i Bergen [PDF]

, 2006
I forbindelse med iverksetting av ny felles lov for offentlige og private universiteter og høgskoler sommeren 2005 ba departementet institusjonene nullstille organisasjons-, styrings- og ledelsesstrukturen for å vurdere de nye mulighetene som loven åpner
Larsen, Ingvild Marheim, Røsdal, Trude
core  

Fast Two-Step Energy Detection for Spectrum Sensing

Journal of Electrical and Computer Engineering, 2015
Spectrum sensing is one of the key tasks in cognitive radio. This paper proposes a fast two-step energy detection (FED) algorithm for spectrum sensing via improving the sampling process of conventional energy detection (CED).
Meiling Lai, Shengliang Peng, Xi Yang, Lin Zhou   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source