An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
From uncertainty to adaptivity : multiscale edge detection and image segmentation [PDF]
This thesis presents the research on two different tasks in computer vision: edge detection and image segmentation (including texture segmentation and motion field segmentation).
Liang, Kung-Hao
core
Competitive policies in the Nordic Energy Research and Innovation Area − eNERGIA: Synthesis report [PDF]
, 2008 The report is the result of the research project Competitive policies in the Nordic Energy Research and Innovation Area (eNERGIA). The project was co-funded by Nordic Energy Research and NIFU STEP.
Klitkou, Antje +3 more
core
Kartlegging av norsk utdanningsforskning [PDF]
, 2007 Denne rapporten er en kartlegging av norsk utdanningsforskning som er eksplorerende av karakter. Oppdragsgiver er Kunnskapsdepartementet, og prosjektet er et ledd i departementets utarbeidelse av en strategi for sektorforskningsansvar på området ...
Borgen, Jorunn Spord +2 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Two-Step Accuracy Improvement for Multitarget Detection in Complex Environment Using UWB Radar
Remote SensingDetecting multiple human targets in indoor scenarios using ultra-wideband (UWB) radar usually involves false detection results caused by the secondary reflections, which might reduce the target detection accuracy and cause a more severe deterioration ...
Zhihuan Liang +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Lifelong learning and work-related training in Norway – an international perspective: Final report from the project ”Framework conditions for investments in training” [PDF]
, 2009 På oppdrag fra Kunnskapsdepartementet gjennomførte NIFU STEP et større prosjekt med formål å undersøke hvilke rammebetingelser som påviker investeringer i kompetanse i Norge og internasjonalt.
Kaloudis, Aris +2 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source