Results 111 to 120 of about 29,380 (303)

Stepped-wedge cluster randomised controlled trials : a generic framework including parallel and multiple-level designs [PDF]

, 2014
Stepped-wedge cluster randomised trials (SW-CRTs) are being used with increasing frequency in health service evaluation. Conventionally, these studies are cross-sectional in design with equally spaced steps, with an equal number of clusters randomised at
Girling, Alan J., Hemming, Karla, Lilford, Richard   +2 more
core   +2 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

DIZZiness treatment through implementation and clinical strategy Tactics-2 (DIZZTINCT-2) project—a clinical trial protocol

Trials
Background The evaluation and management of acute vertigo presentations is challenging for both patients and physicians. Benign paroxysmal positional vertigo (BPPV), acute unilateral vestibulopathy (e.g., vestibular neuritis), and stroke are priority ...
William J. Meurer, Stacy Park, Huong Nguyen, Silvia R. Paz, Molly O. Jancis, Julliane Bacerdo, Aileen S. Baecker, Prasanth Manthena, Navdeep S. Sangha, Chengyi Zheng, Lawrence C. An, Terry D. Fife, Adam L. Sharp, James F. Burke, Kevin A. Kerber   +14 more
doaj   +1 more source

Leveraging Contact Network Structure in the Design of Cluster Randomized Trials [PDF]

, 2016
Background: In settings like the Ebola epidemic, where proof-of-principle trials have succeeded but questions remain about the effectiveness of different possible modes of implementation, it may be useful to develop trials that not only generate ...
DeGruttola, Victor, Harling, Guy, Onnela, Jukka-Pekka, Wang, Rui   +3 more
core   +3 more sources

Assessing Mediation in Cross‐Sectional Stepped Wedge Cluster Randomized Trials

Statistics in Medicine
ABSTRACT Mediation analysis has been studied for independent data, but relatively little work has been done for correlated data observed under stepped wedge cluster randomized trials (SW‐CRTs). Motivated by the need to understand the effect mechanisms in SW‐CRTs, we develop a set of regression‐based methods for ...
Zhiqiang Cao, Fan Li
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Overcoming challenges in real‐world evidence generation: An example from an Adult Medical Care Coordination program

Learning Health Systems
The Adult Medical Care Coordination program (“the program”) was implemented at Mayo Clinic to promote patient self‐management and improve 30‐day unplanned readmission for patients with high risk for readmission after hospital discharge.
Samuel T. Savitz, Michelle A. Lampman, Shealeigh A. Inselman, Ruchita Dholakia, Vicki L. Hunt, Angela B. Mattson, Robert J. Stroebel, Pamela J. McCabe, Stephanie G. Witwer, Bijan J. Borah   +9 more
doaj   +1 more source

Crowdsourcing to promote HIV testing among MSM in China: study protocol for a stepped wedge randomized controlled trial. [PDF]

, 2017
BACKGROUND: HIV testing for marginalized populations is critical to controlling the HIV epidemic. However, the HIV testing rate among men who have sex with men (MSM) in China remains low. Crowdsourcing, the process of shifting individual tasks to a group,
SESH Study Group, Tucker, Joseph D
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source