Stepped-wedge cluster randomised controlled trials : a generic framework including parallel and multiple-level designs [PDF]
, 2014 Stepped-wedge cluster randomised trials (SW-CRTs) are being used with increasing frequency in health service evaluation. Conventionally, these studies are cross-sectional in design with equally spaced steps, with an equal number of clusters randomised at
Girling, Alan J. +2 more
core +2 more sources
Evaluation of a community-based integrated care model (CIE) for frail older people in rural Foshan, China: study protocol for a stepped-wedge cluster randomized controlled trial {1} [PDF]
, 2023 Fengjiao Xie +4 more
openalex +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Reporting quality of stepped wedge design randomized trials: a systematic review protocol
Clinical Epidemiology, 2016 Alex Thabane,1,2 Brittany B Dennis,3,4 Olga Gajic-Veljanoski,3,9,10 James Paul,2,3 Lehana Thabane2,3,5-8 1Life Sciences Program, Queen’s University, Kingston, ON, Canada; 2Department of Anesthesia, McMaster University Hamilton ON, 3Department of ...
Thabane A +4 more
doaj
Design of the HIV Prevention Trials Network (HPTN) Protocol 054: A cluster randomized crossover trial to evaluate combined access to Nevirapine in developing countries [PDF]
, 2003 HPTN054 is a cluster randomized trial designed to compare two approaches to providing single dose nevirapine to HIV-seropositive mothers and their infants to prevent mother-to-child transmission of HIV in resource limited settings.
Goldenberg, Robert L. +7 more
core +1 more source
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
Leveraging Contact Network Structure in the Design of Cluster Randomized Trials [PDF]
, 2016 Background: In settings like the Ebola epidemic, where proof-of-principle trials have succeeded but questions remain about the effectiveness of different possible modes of implementation, it may be useful to develop trials that not only generate ...
DeGruttola, Victor +3 more
core +3 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Contemporary Clinical Trials Communications, 2017 Background: The stepped wedge trial (SWT) design is a type of the randomized clinical trial (RCT) design in which clusters or individuals are randomly and sequentially crossed over from control to intervention over a number of time periods.
Mei Wang +7 more
doaj +1 more source
The effect of a complementary e-learning course on implementation of a quality improvement project regarding care for elderly patients: a stepped wedge trial [PDF]
, 2012 Background Delirium occurs frequently in elderly hospitalised patients and is associated with higher mortality, increased length of hospital stay, functional decline, and admission to long-term care.
CA Brown +35 more
core +4 more sources