Results 121 to 130 of about 31,328 (346)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

DIZZiness treatment through implementation and clinical strategy Tactics-2 (DIZZTINCT-2) project—a clinical trial protocol

Trials
Background The evaluation and management of acute vertigo presentations is challenging for both patients and physicians. Benign paroxysmal positional vertigo (BPPV), acute unilateral vestibulopathy (e.g., vestibular neuritis), and stroke are priority ...
William J. Meurer, Stacy Park, Huong Nguyen, Silvia R. Paz, Molly O. Jancis, Julliane Bacerdo, Aileen S. Baecker, Prasanth Manthena, Navdeep S. Sangha, Chengyi Zheng, Lawrence C. An, Terry D. Fife, Adam L. Sharp, James F. Burke, Kevin A. Kerber   +14 more
doaj   +1 more source

Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations [PDF]

, 2017
Health care-associated infections (HAI) are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide.
A Higgins, A Jamal, A Lipitz-Snyderman, A Pinto, AF Vicca, AJ Howie, AM Yinnon, AR Marra, AS Mathai, B Allegranzi, BA Mark, BN Reames, BS Koll, BW Thomas, C Brandt, C Fuller, CS Cocanour, D Fisher, D Pittet, D Pittet, D Quiros, DD Wirtschafter, DG Bundy, DJ Birnbach, DM Henderson, E Creamer, Effective Practice and Organisation of Care (EPOC), EG Shepherd, EL Geubbels, EL Larson, F L’Heriteau, F Schwab, G Pontivivo, GB Allen, GH Guyatt, HW Kilbride, I Zuschneid, International Health Regulations, J Alonso-Echanove, J Bion, J Blatnik, J Mayer, J Robert, JA Al-Tawfiq, JA Marsteller, JB Cunningham, JB Cunningham, JB Cunningham, JH Barsuk, JH Jang, JJ Anderson, JW Lederer Jr, KB Kirkland, KB Stevenson, L Bouadma, L Charrier, L Gerolemou, L Johnson, L Rubinson, LA Mermel, LJ Damschroder, LL McKinley, M Thomas, M Virtanen, M Whitby, MA Borg, MA Borg, MD Koff, ML Grayson, ML McLaws, ML McLaws, ML Render, ML Schweizer, MR Miller, MR Miller, N Petrosillo, P Eggimann, P Gastmeier, P Gastmeier, P Gastmeier, P Gastmeier, PW Nicol, R Jain, R Peredo, RJ Sherertz, RM Sladek, RW Haley, S Barwolff, S Hansen, S Hugonnet, S Hugonnet, S Hugonnet, S Newitt, S Nijssen, SA Creedon, SC Joshi, SI Doron, SK Fridkin, SM Brown, SR Lieber, TR Talbot, V Rodriguez, VA DePalo, VD Rosenthal, VD Rosenthal, VD Rosenthal, VD Rosenthal, W Moongtui, W Turnberg, W Zingg, W Zingg, W Zingg, WN Viana, YL Kwok   +113 more
core   +6 more sources

Assessing Mediation in Cross‐Sectional Stepped Wedge Cluster Randomized Trials

Statistics in Medicine
ABSTRACT Mediation analysis has been studied for independent data, but relatively little work has been done for correlated data observed under stepped wedge cluster randomized trials (SW‐CRTs). Motivated by the need to understand the effect mechanisms in SW‐CRTs, we develop a set of regression‐based methods for ...
Zhiqiang Cao, Fan Li
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Overcoming challenges in real‐world evidence generation: An example from an Adult Medical Care Coordination program

Learning Health Systems
The Adult Medical Care Coordination program (“the program”) was implemented at Mayo Clinic to promote patient self‐management and improve 30‐day unplanned readmission for patients with high risk for readmission after hospital discharge.
Samuel T. Savitz, Michelle A. Lampman, Shealeigh A. Inselman, Ruchita Dholakia, Vicki L. Hunt, Angela B. Mattson, Robert J. Stroebel, Pamela J. McCabe, Stephanie G. Witwer, Bijan J. Borah   +9 more
doaj   +1 more source

Effects of Acupoint Stimulation Combined with Low-frequency Pulsed Electrotherapy on Labor Pain in Women undergoing Trial of Labor: protocol for a stepped wedge cluster randomized controlled trial [PDF]

, 2023
Yiyun Gu, Xiaojiao Wang, Chunxiang Zhu, Hui Min, Jing Zhang, Liping Mao, Hua Gao, Hangyun Sun, Xinli Zhu, Chunyi Gu   +9 more
openalex   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Reducing Medical Admissions into Hospital through Optimising Medicines (REMAIN HOME) Study: Protocol for a stepped wedge, cluster randomised trial [PDF]

, 2017
Introduction: A model of general practitioner (GP) and pharmacist collaboration in primary care may be an effective strategy to reduce medication-related problems and provide better support to patients after discharge.
Arnold, Australian Council on Safety and Quality in Health Care, Belleli, Bonnet-Zamponi, Campbell, Campbell, Chan, Coleman, Davies, Freeman, Freeman, Hansen, Hawes, Hazen, Hemming, Hemming, Holland, Howell, Hussey, Independent Hospital Pricing Authority, Independent Hospital Pricing Authority, Jack, Jencks, Kilcup, Kwan, Leppin, Mekonnen, Mueller, Naunton, Pal, Picker, Polinski, Rockwood, Stowasser, Tan, Tedesco, Unroe, Van, Vashi, Williams, Wimmer   +40 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source