Results 131 to 140 of about 31,328 (346)

The Devon Active Villages Evaluation (DAVE) trial: study protocol of a stepped wedge cluster randomised trial of a community-level physical activity intervention in rural southwest England [PDF]

, 2012
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Although physical inactivity has been linked with numerous chronic health conditions and overall ...
Hillsdon, Melvyn, Metcalf, B, Rees, Tim, Solomon, Emma, Ukoumunne, Obioha C.   +4 more
core   +2 more sources

swpermute: Permutation tests for Stepped-Wedge Cluster-Randomised Trials. [PDF]

The Stata journal, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the Stata command permute does not produce valid tests in this setting because individual observations are not exchangeable.
Thompson, Jennifer, Davey, Calum, Hayes, Richard, Hargreaves, James, Fielding, Katherine   +4 more
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Promoting Recruitment using Information Management Efficiently (PRIME): a stepped-wedge, cluster randomised trial of a complex recruitment intervention embedded within the REstart or Stop Antithrombotics Randomised Trial

Trials, 2017
Background Few interventions are proven to increase recruitment in clinical trials. Recruitment to RESTART, a randomised controlled trial of secondary prevention after stroke due to intracerebral haemorrhage, has been slower than expected.
Amy E. Maxwell, Richard A. Parker, Jonathan Drever, Anthony Rudd, Martin S. Dennis, Christopher J. Weir, Rustam Al-Shahi Salman   +6 more
doaj   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

The POP (Permanent Supportive Housing Overdose Prevention) Study: protocol for a hybrid type 3 stepped-wedge cluster randomized controlled trial [PDF]

, 2023
Kelly M. Doran, Allison Torsiglieri, Stephanie Blaufarb, Patricia Hernández, Emily M. Melnick, Lauren Velez, Charles M. Cleland, Charles J. Neighbors, Megan A. O’Grady, Donna Shelley   +9 more
openalex   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: protocol for a cluster randomized stepped-wedge trial [PDF]

, 2019
Tinka Bakker, Joanna E. Klopotowska, Saeid Eslami, Dylan W. de Lange, Rob J. van Marum, Heleen van der Sijs, Evert de Jonge, Dave A. Dongelmans, N. F. de Keizer, Ameen Abu‐Hanna   +9 more
openalex   +1 more source

Long‐Term Opioids in Gout: A Matched Cohort Study From the Veterans Health Administration

Arthritis Care &Research, EarlyView.
Objective Though used frequently to treat flare, risk of long‐term opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed long‐term opioids over time.
Lindsay N. Helget, Bryant R. England, Punyasha Roul, Harlan Sayles, Tuhina Neogi, James R. O'Dell, Joshua F. Baker, Ted R. Mikuls   +7 more
wiley   +1 more source

Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol.

PLoS ONE
BackgroundAcute application of adjunctive negative pressure wound therapy (NPWT) significantly improves time to re-epithelialization in pediatric burn patients. This adjunctive treatment has not yet been broadly or routinely adopted as a standard primary
Maleea D Holbert, Fiona Wood, Andrew J A Holland, Warwick Teague, Roy M Kimble, Dianne Crellin, Cody C Frear, Kristen Storey, Natalie Phillips, Yvonne Singer, Tanesha A Dimanopoulos, Lisa Martin, Leila Cuttle, Dimitrios Vagenas, Steven M McPhail, Pauline Calleja, Jed Duff, Alexandra De Young, Bronwyn R Griffin   +18 more
doaj   +1 more source