Results 31 to 40 of about 29,380 (303)

The optimal design of stepped wedge trials with equal allocation to sequences and a comparison to other trial designs. [PDF]

, 2017
Background/Aims We sought to optimise the design of stepped wedge trials with an equal allocation of clusters to sequences and explored sample size comparisons with alternative trial designs.
Copas, Andrew, Fielding, Katherine, Hargreaves, James, Thompson, Jennifer A   +3 more
core   +2 more sources

The batched stepped wedge design: A design robust to delays in cluster recruitment [PDF]

, 2022
Stepped wedge designs are an increasingly popular variant of longitudinal cluster randomized trial designs, and roll out interventions across clusters in a randomized, but step‐wise fashion. In the standard stepped wedge design, assumptions regarding the
Bowden, R, Forbes, AB, Hooper, R, Kasza, J   +3 more
core   +1 more source

Adapting and pilot testing an HIV and intersectional stigma reducing intervention for Dominican Republic healthcare contexts: Protocol for translational research

Contemporary Clinical Trials Communications, 2022
Background: This protocol details the adaptation and pilot testing of the Finding Respect and Ending Stigma around HIV (FRESH) intervention in Dominican Republic.
Henna Budhwani, Robert Paulino-Ramírez, John Waters, Christyenne L. Bond, Ingrid Ruiz, Dustin M. Long, Nelson Varas-Díaz, Sylvie Naar, Laura Nyblade, Janet M. Turan   +9 more
doaj   +1 more source

HELP! Problems in executing a pragmatic, randomized, stepped wedge trial on the Hospital Elder Life Program to prevent delirium in older patients

Trials, 2017
Background A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered.
Noor Heim, Henk F. van Stel, Roelof G. Ettema, Roos C. van der Mast, Sharon K. Inouye, Marieke J. Schuurmans   +5 more
doaj   +1 more source

Stepped wedge randomised controlled trials: systematic review of studies published between 2010 and 2014. [PDF]

, 2015
BACKGROUND: In a stepped wedge, cluster randomised trial, clusters receive the intervention at different time points, and the order in which they received it is randomised. Previous systematic reviews of stepped wedge trials have documented a steady rise
Baio, Gianluca, Beard, Emma, Copas, Andrew, Davey, Calum, Fielding, Katherine L, Hargreaves, James, Lewis, James J, Omar, Rumana Z, Ononge, Sam, Osrin, David, Prost, Audrey, Thompson, Jennifer A   +11 more
core   +2 more sources

Promoting Independence Through quality dementia Care at Home (PITCH): a research protocol for a stepped-wedge cluster-randomised controlled trial

Trials, 2021
Background Home care service providers are increasingly supporting clients living with dementia. Targeted and comprehensive dementia-specific training for home care staff is necessary to meet this need. This study evaluates a training programme delivered
Steven Savvas, Anita M. Y. Goh, Frances Batchelor, Colleen Doyle, Erica Wise, Esther Tan, Anita Panayiotou, Sue Malta, Margaret Winbolt, Phillip Clarke, Jason Burton, Lee-Fay Low, Samantha M. Loi, Anne Fairhall, Meg Polacsek, Jay Stiles, Fenny Muliadi, Nadia Chau, Samuel Scherer, David Ames, Tanara Vieira Sousa, Briony Dow   +21 more
doaj   +1 more source

A pragmatic, multi-centered, stepped wedge, cluster randomized controlled trial pilot of the clinical and cost effectiveness of a complex Stroke Oral healthCare intervention pLan Evaluation II (SOCLE II) compared with usual oral healthcare in stroke wards [PDF]

, 2019
BACKGROUND: Patients with stroke-associated pneumonia experience poorer outcomes (increased hospital stays, costs, discharge dependency, and risk of death).
Bain, Brenda Jean, Barr, John, Bowers, Naomi, Brady, Marian C., Chalmers, Campbell, Colins, Marissa, Gray, Heather, Keerie, Catriona, Langhorne, Peter, Pollock, Alex, Stott, David J., Sweeney, Petrina, Weir, Christopher J.   +12 more
core   +2 more sources

Permutation tests for stepped-wedge cluster-randomized trials [PDF]

The Stata Journal: Promoting communications on statistics and Stata, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the permute command does not produce valid tests in this setting because individual observations are not exchangeable. We introduce the swpermute command, which permutes clusters to sequences to maintain exchangeability ...
Jennifer Thompson, Calum Davey, Richard Hayes, James Hargreaves, Katherine Fielding   +4 more
openaire   +1 more source

The impact of varying cluster size in cross-sectional stepped-wedge cluster randomised trials

BMC Medical Research Methodology, 2019
Background Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for clustering.
James Thomas Martin, Karla Hemming, Alan Girling   +2 more
doaj   +1 more source

Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies [PDF]

, 2015
Background: Three arguments are usually invoked in favour of stepped wedge cluster randomised controlled trials: the logistic convenience of implementing an intervention in phases, the ethical benefit of providing the intervention to all clusters, and ...
Abubakar, Ibrahim, Ayles, Helen, Binik, Ariella, De Allegri, Manuela, Dreischulte, Tobias, Lewis, James J., Mouchoux, Christelle, Osrin, David, Prost, Audrey, Roy, Anjana   +9 more
core   +5 more sources