Trials, 2017 Background A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered.
Noor Heim +5 more
doaj +1 more source
Evaluation of a novel
Arthritis Care &Research, Accepted Article.Objective We developed a novel EHR sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk +16 more
openalex +2 more sources
Trials, 2021 Background Home care service providers are increasingly supporting clients living with dementia. Targeted and comprehensive dementia-specific training for home care staff is necessary to meet this need. This study evaluates a training programme delivered
Steven Savvas +21 more
doaj +1 more source
A pragmatic, multi-centered, stepped wedge, cluster randomized controlled trial pilot of the clinical and cost effectiveness of a complex Stroke Oral healthCare intervention pLan Evaluation II (SOCLE II) compared with usual oral healthcare in stroke wards [PDF]
, 2019 BACKGROUND: Patients with stroke-associated pneumonia experience poorer outcomes (increased hospital stays, costs, discharge dependency, and risk of death).
Bain, Brenda Jean +12 more
core +2 more sources
Permutation tests for stepped-wedge cluster-randomized trials [PDF]
The Stata Journal: Promoting communications on statistics and Stata, 2019 Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the permute command does not produce valid tests in this setting because individual observations are not exchangeable. We introduce the swpermute command, which permutes clusters to sequences to maintain exchangeability ...
Jennifer Thompson +4 more
openaire +1 more source
The impact of varying cluster size in cross-sectional stepped-wedge cluster randomised trials
BMC Medical Research Methodology, 2019 Background Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for clustering.
James Thomas Martin +2 more
doaj +1 more source
Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies [PDF]
, 2015 Background: Three arguments are usually invoked in favour of stepped wedge cluster randomised controlled trials: the logistic convenience of implementing an intervention in phases, the ethical benefit of providing the intervention to all clusters, and ...
Abubakar, Ibrahim +9 more
core +5 more sources
BMC Public Health, 2010 Background Approximately 55,000 children in New Zealand do not eat breakfast on any given day. Regular breakfast skipping has been associated with poor diets, higher body mass index, and adverse effects on children's behaviour and academic performance ...
Maddison Ralph +6 more
doaj +1 more source
BMC Medical Research Methodology, 2022 Background Stepped wedge trials are an appealing and potentially powerful cluster randomized trial design. However, they are frequently implemented with a small number of clusters.
Kelsey L. Grantham +4 more
doaj +1 more source
Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system : study protocol for a stepped-wedge randomized trial [PDF]
, 2017 Background: There is robust clinical evidence to support offering early access to antiretroviral treatment (ART) to all HIV-positive individuals, irrespective of disease stage, to both improve patient health outcomes and reduce HIV incidence. However, as
Barnighausen, Till +11 more
core +5 more sources