Results 51 to 60 of about 29,380 (303)

The prevention and reduction of weight loss in an acute tertiary care setting: Protocol for a pragmatic stepped wedge randomised cluster trial (the PRoWL Project) [PDF]

, 2013
Background: Malnutrition, with accompanying weight loss, is an unnecessary risk in hospitalised persons and often remains poorly recognised and managed.
A Dickinson, A Jaafar, A Kitson, A Kitson, A Kitson, A Westergren, AC Milne, Age UK, AL Kitson, Alison L Kitson, Alison Shanks, AM Mudge, AM Mudge, Australian Council on Healthcare Standards, C Brown, C Davis, C Liddy, C Mouchoux, C Watterson, C Watterson, C Xia, CA Brown, CA Estabrooks, CA Lamb, CA Russell, D Jefferies, D Moher, D Vanderkroft, DG Duncan, DH Sullivan, DH Sullivan, E Parsons, F Neelemaat, GS Doig, HM Kruizenga, I Boutron, I Boutron, Ian Chapman, J Crosbie, J Kondrup, J Larsson, J Porter, JC Hoekstra, JP McWhirter, K Walton, KE Covinsky, L Bradley, L Brugler, L Villalon, L Wright, Leslye Long, LJ Ross, M Elia, M Elia, M Elia, M Hickson, M Zwarenstein, MA Hussey, MF Tsang, MH Middleton, MK Campbell, N Kagansky, N Laird, National Institute for Health and Clinical Excellence, ND Mdege, R Bailey, R Pawson, R Raja, R Thibault, R Wiechula, Rick Wiechula, RJ Stratton, RJ Stratton, RJ Stratton, RJ Stratton, S Holmes, S Klein, S Naithani, S Wong, SM Green, SM Green, SM Schneider, Stijn Soenen, TF Amaral, Timothy J Schultz, TJ Schultz   +85 more
core   +3 more sources

Developing and evaluating a lay health worker delivered implementation intervention to decrease engagement disparities in behavioural parent training: a mixed methods study protocol. [PDF]

, 2019
IntroductionBehavioural parent training (BPT) programmes are effective in preventing and treating early-onset conduct problems and child maltreatment. Unfortunately, pervasive mental health service disparities continue to limit access to and engagement ...
Barnett, Miya, Kia-Keating, Maryam, Landsverk, John, Lau, Anna S, Miranda, Jeanne, Saldana, Lisa   +5 more
core   +1 more source

Stepped-wedge cluster randomised trials: where, when and why? [PDF]

Trials, 2015
The stepped wedge (SW) cluster randomised trial (CRT) design is being utilised at increasing pace. However, little is known about the standard of reporting of such trials, or how useful the design has proven to be in hindsight. Moreover, much debate exists around when the design should be preferred to the more classical parallel group (PG) CRT.
Grayling, Michael, Wason, James, Mander, Adrian   +2 more
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A website for cluster randomised trials including stepped wedge: facilitating quality trials and methodological research

Trials
Background A cluster randomised trial is a randomised controlled trial in which groups of individuals (clusters) are randomised to treatment arms.
Claire L. Chan, Clémence Leyrat, James Martin, Jennifer Thompson, Elizabeth L. Turner, Sandra M. Eldridge   +5 more
doaj   +1 more source

PrEP uptake and HIV viral suppression when PrEP is integrated into Ugandan ART clinics for HIV-negative members of HIV-serodifferent couples: A stepped wedge cluster randomized trial

EClinicalMedicine, 2022
Summary: Background: Global scale-up of HIV pre-exposure prophylaxis (PrEP) includes services to HIV-negative people in partnerships with people living with HIV (serodifferent couples).
Renee Heffron, Timothy R. Muwonge, Katherine K. Thomas, Florence Nambi, Lylianne Nakabugo, Joseph Kibuuka, Dorothy Thomas, Erika Feutz, Allison Meisner, Norma C. Ware, Monique A. Wyatt, Jane M. Simoni, Ingrid T. Katz, Herbert Kadama, Jared M. Baeten, Andrew Mujugira, Renee Heffron, (protocol chair), Jared M. Baeten, Jane Simoni, Deborah Donnell, Ruanne Barnabas, Katherine K. Thomas, Dorothy Thomas, Erika Feutz, Cole Grabow, Allison Meisner, Kristin Ciccarelli, Caitlin Scoville, Katrina Ortblad, Andrew Mujugira, Timothy R. Muwonge, Joseph Kibuuka, Lylianne Nakabugo, Florence Nambi, Mai Nakitende, Diego Izizinga, Vicent Kasita, Brenda Kamusiime, Alisaati Nalumansi, Collins Twesige, Grace Kakoola, Charles Brown, Sylvia Namanda, Herbert Kadama, Norma C. Ware, Monique A. Wyatt, Emily Pisarski, Ingrid T. Katz   +47 more
doaj   +1 more source

Randomization-Based Confidence Intervals for Cluster Randomized Trials [PDF]

, 2020
In a cluster randomized trial (CRT), groups of people are randomly assigned to different interventions. Existing parametric and semiparametric methods for CRTs rely on distributional assumptions or a large number of clusters to maintain nominal ...
Rabideau, Dustin J, Wang, Rui
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum

Trials, 2023
We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer.
Jeph Herrin, Lila J. Finney Rutten, Kathryn J. Ruddy, Kurt Kroenke, Andrea L. Cheville   +4 more
doaj   +1 more source

RACE-IT – Rapid Acute Coronary Syndrome Exclusion using the Beckman Coulter Access high-sensitivity cardiac troponin I: A stepped-wedge cluster randomized trial

Contemporary Clinical Trials Communications, 2021
Background: Protocols utilizing high-sensitivity cardiac troponin (hs-cTn) assays for the evaluation of suspected acute coronary syndrome (ACS) in the emergency department (ED) have been gaining popularity across the US and the world.
Joseph Miller, Bernard Cook, Gulmohar Singh-Kucukarslan, Amy Tang, Shooshan Danagoulian, Gerard Heath, Ziad Khalifa, Phillip Levy, Simon A. Mahler, Nicholas Mills, James McCord   +10 more
doaj   +1 more source