Results 61 to 70 of about 29,380 (303)

Health Economic Evaluation Alongside Stepped Wedge Trials: A Methodological Systematic Review [PDF]

PharmacoEconomics, 2020
Recently, there has been an increase in use of the stepped wedge trial (SWT) design in the context of health services research, due to its pragmatic and methodological advantages over the parallel group design.Our objective was to summarise the statistical methods used when conducting economic evaluations alongside SWTs.A systematic literature search ...
Thomas Lung, Lei Si, Richard Hooper, Gian Luca Di Tanna   +3 more
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

阶梯整群随机试验 Stepped Wedge Cluster Randomized Trials

Zhongguo cuzhong zazhi, 2023
阶梯整群随机试验（stepped wedge cluster randomized trial，SW-CRT）是一种新型的研究设计，通常用于评价整群的服务或政策干预效果。该设计不需要单独设立对照，在设计初始阶段，所有整群均不暴露于干预，随后每一个观察期随机一组整群接受干预，进入干预组，直到所有整群均接受干预。本文从SW-CRT的基本原理、类别、研究设计、样本量计算、统计学方法和报告规范等方面进行介绍，为开展SW-CRT研究提供参考。 Abstract: The stepped wedge ...
王孟, 王春娟, 李子孝, 谷鸿秋
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Vaccine trials during a pandemic: potential approaches to ethical dilemmas

Trials, 2021
Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge.
Manaf Alqahtani, Saad I. Mallah, Nigel Stevenson, Sally Doherty   +3 more
doaj   +1 more source

Parable of two agencies, one of which randomizes [PDF]

, 2010
This article examines the design of evaluations in settings where there is a choice as to how an intervention is to be introduced and evaluated. It uses data from a supervision program for offenders on probation in the UK (Bruce and Hollin forthcoming ...
Bowles, R., McDougall, C., Pearson, Dominic, Torgerson, D.   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Rollout trial designs in implementation research are often necessary and sometimes preferred

Implementation Science
Background Rollout designs, which include stepped wedge designs, are defined by staggered implementation of new or alternative programs or services. Critiques of stepped wedge and other rollout designs have raised concerns regarding the confounding of ...
Gregory E. Simon, Bryan R. Garner, Justin D. Smith, Peter A. Wyman, Theresa E. Matson, Lia Chin-Purcell, Ian Cero, Wouter Vermeer, Kimberly A. Johnson, Guillermo Prado, C. Hendricks Brown   +10 more
doaj   +1 more source

Ethnolinguistic concordance and the receipt of postpartum IUD counseling services in Sri Lanka. [PDF]

, 2018
CONTEXT: Ethnic and linguistic concordance are important dimensions of the patient-physician relationship, and are linked to health care disparities.
Canning, David, de Silva, Ranjith, Karra, Mahesh, Pearson, Erin, Samarasekera, Arnjali, Shah, Iqbal   +5 more
core   +1 more source

Power Analysis for Stepped Wedge Trials with Two Treatments [PDF]

, 2020
AbstractStepped wedge designs (SWDs) are designs for cluster randomized trials that feature staggered, unidirectional cross-over, typically from a control to a treatment condition. Existing literature on statistical power for SWDs primarily focuses on designs with a single treatment.
Sundin, Phillip T., Crespi, Catherine M.
openaire   +2 more sources