Results 71 to 80 of about 31,328 (346)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Rollout trial designs in implementation research are often necessary and sometimes preferred

Implementation Science
Background Rollout designs, which include stepped wedge designs, are defined by staggered implementation of new or alternative programs or services. Critiques of stepped wedge and other rollout designs have raised concerns regarding the confounding of ...
Gregory E. Simon, Bryan R. Garner, Justin D. Smith, Peter A. Wyman, Theresa E. Matson, Lia Chin-Purcell, Ian Cero, Wouter Vermeer, Kimberly A. Johnson, Guillermo Prado, C. Hendricks Brown   +10 more
doaj   +1 more source

Ethnolinguistic concordance and the receipt of postpartum IUD counseling services in Sri Lanka. [PDF]

, 2018
CONTEXT: Ethnic and linguistic concordance are important dimensions of the patient-physician relationship, and are linked to health care disparities.
Canning, David, de Silva, Ranjith, Karra, Mahesh, Pearson, Erin, Samarasekera, Arnjali, Shah, Iqbal   +5 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Parable of two agencies, one of which randomizes [PDF]

, 2010
This article examines the design of evaluations in settings where there is a choice as to how an intervention is to be introduced and evaluated. It uses data from a supervision program for offenders on probation in the UK (Bruce and Hollin forthcoming ...
Bowles, R., McDougall, C., Pearson, Dominic, Torgerson, D.   +3 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The current use of feasibility studies in the assessment of feasibility for stepped-wedge cluster randomised trials: a systematic review

BMC Medical Research Methodology, 2019
Background Stepped-wedge cluster randomised trials (SW-CRTs) are a pragmatic trial design, providing an unprecedented opportunity to increase the robustness of evidence underpinning implementation and quality improvement interventions.
Caroline A. Kristunas, Karla Hemming, Helen Eborall, Sandra Eldridge, Laura J. Gray   +4 more
doaj   +1 more source

The impact of the Trauma Triage App on pre-hospital trauma triage: design and protocol of the stepped-wedge, cluster-randomized TESLA trial

Diagnostic and Prognostic Research, 2020
Background Field triage of trauma patients is crucial to get the right patient to the right hospital within a particular time frame. Minimization of undertriage, overtriage, and interhospital transfer rates could substantially reduce mortality rates ...
Rogier van der Sluijs, Audrey A. A. Fiddelers, Job F. Waalwijk, Johannes B. Reitsma, Miranda J. Dirx, Dennis den Hartog, Silvia M. A. A. Evers, J. Carel Goslings, W. Margreet Hoogeveen, Koen W. Lansink, Luke P. H. Leenen, Mark van Heijl, Martijn Poeze   +12 more
doaj   +1 more source

Evaluation of multiple interventions using a stepped wedge design [PDF]

, 2017
Background: Stepped wedge cluster randomized trials are a class of unidirectional crossover studies that have historically been limited to evaluating a single intervention.
Hughes, James, Li, Lingyu, Lyons, Vivian H, Rowhani-Rahbar, Ali   +3 more
core   +1 more source

Randomised controlled trials of complex interventions and large-scale transformation of services [PDF]

, 2016
Complex interventions and large-scale transformations of services are necessary to meet the health-care challenges of the 21st century. However, the evaluation of these types of interventions is challenging and requires methodological development ...
Barratt, Helen, Bower, Peter, Campbell, Marion, Moore, Laurence, Zwarenstein, Merrick   +4 more
core   +1 more source