Results 101 to 110 of about 12,197 (302)
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Current expertise and experience on stepped chute flows: hydraulics of stepped spillways
, 1999 Stepped channels and spillways are used since more than 3,000 years. Recently, new construction materials (e.g. RCC, gabions) have increased the interest for stepped chutes.
Chanson, Hubert
core
Moravian Geographical Reports, 2016 The stepped-bed system, with a step-like longitudinal profile, is typical morphology in steep headwater streams. These systems are created by a series of coarse sediments or instream wood (steps with supercritical flows) interspaced with finer material ...
Přibyla Zdeněk +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Performance of Type III stilling basins for stepped spillways [PDF]
, 2016 Presented at the Protections 2016: 2nd international seminar on dam protection against overtopping: concrete dams, embankment dams, levees, tailings dams held on 7th-9th September, 2016, at Colorado State University in Fort Collins, Colorado, USA.
Svoboda, C., author +3 more
core +1 more source
Channel assisted noise propagation in a two-step cascade
Chaos: An Interdisciplinary Journal of Nonlinear ScienceSignal propagation in biochemical networks is characterized by the inherent randomness in gene expression and fluctuations of the environmental components, commonly known as intrinsic and extrinsic noise, respectively. We present a theoretical framework for noise propagation in a generic two-step cascade (S→X→Y) regarding intrinsic and extrinsic noise.
Mintu Nandi +3 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
EFFECT OF HYDRAULIC AND GEOMETRICAL PROPERTIES ON STEPPED CASCADE AERATION SYSTEM [PDF]
Journal of Engineering Science and Technology, 2017 Stepped cascade aeration system is commonly used to aerate the water and wastewater to increase the dissolved oxygen during pre and post treatment process.
VEDHACHALAM RATHINAKUMAR +2 more
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano +11 more
wiley +1 more source
Comparison of stepped and smooth spillway effects on stream reaeration
, 2021 The oxygen transfer at a hydraulic structure happens by self-aeration through the spillway and by flow aeration in the hydraulic jump downstream of the hydraulic structure.
Aras, Egemen, Berkun, Mehmet
core