Results 81 to 90 of about 12,197 (302)

Anti-angiogenic activity of chloride and potassium channel modulators: repurposing ion channel modulators

Future Journal of Pharmaceutical Sciences, 2020
Background Excessive angiogenesis can be the root cause of many pathological conditions. Various types of ion channels are found on the endothelial cells. These ion channels play a vital role in the multi-stepped process of angiogenesis.
Chandana Kamili, Hima Sowmya Kandoti, Sharadha Radhakrishnan, Abbulu Konde, Uma Maheshwara Rao Vattikutti   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The Hydraulics of Stepped Chutes and Spillways [PDF]

, 2002
The stepped channel design have been used for more than 3,500 years (chapter 2). A significant number of dams were built with overflow stepped spillways during the 19th century and early 20th century, before the design technique became outdated with the ...
Chanson, Hubert
core  

High-Power External Spatial Beam Combining of 7-Channel Quantum Cascade Lasers Emitting at ~8.5 μm

Photonics
Based on the demand for high-power output, a spatial beam combining 7-channel quantum cascade lasers (QCLs) is demonstrated in this paper. A “2 + 3 + 2” stepped structure is designed to convert the seven beam spots into a circular arrangement.
Haibo Dong, Xuyan Zhou, Man Hu, Yuan Ma, Aiyi Qi, Weiqiao Zhang, Wanhua Zheng   +6 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Experimental study of flash flood wave down a stepped channel

工程科学与技术, 2011
:Abstract:Flood waves resulting from flash floods have been responsible for numerous damage and losses of life. In the present study, an experiment was conducted to investigate surging waters down a stepped channel, which is 2.4m long, 0.5m wide and with
Yang Yang, Cao Shu-you, Yang Feng-guang
doaj  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

The Great Ships; PTBoats

, 2017
The Great Ships; PT Boats narrated by Roger Mudd for the History Channel. An in-depth description of the once famous PT, or Patrol Torpedo Boat, ranging from the invention of the PT boat, to the weaponry equipped, to war stories, and to their ultimate ...
History Channel
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Analysis and Designing of New Broadband Power Divider Using Stepped Impedance for WLAN and 5G Applications [PDF]

Journal of Microwaves, Optoelectronics and Electromagnetic Applications
The development of radio frequency circuits is currently guided mainly through two objectives, which are size reduction and performance improvement of devices.
Abdelhadi Ennajih, Azzeddine Sardi, Ahmed Errkik   +2 more
doaj   +1 more source