Results 71 to 80 of about 12,197 (302)

Turbulence manipulation in air–water flows on a stepped chute: An experimental study [PDF]

, 2008
In a stepped channel operating with large flow rates, the flow skims over the pseudo-bottom formed by the step edges as a coherent stream. Intense three-dimensional recirculation is maintained by shear stress transmission from the mainstream to the step ...
Chanson, Hubert, Gonzalez, Carlos A.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Hydraulics of skimming flows over stepped channels and spillways [PDF]

Journal of Hydraulic Research, 1994
Stepped channel applications include a broad range of domains. A detailed review (past and present) was published by the author (Chanson 1995). To date most studies on gepped chutes applies to gradually variedflows in rectangular prismatic channels with horizontal. The three-dimensional features of stepped chute flows are not accounted.
openaire   +4 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Hydraulics of stepped structure : importance of flow regimes on stepped chutes and practical application in developing countries

, 2003
Recent developments in construction of large dams, reservoirs and channels amplified the improvement of the design of adequate flow release facilities. Chutes and different type of spillways are used t6 evacuate the excess waters without major damage of ...
Llano Gutierrez, S.
core  

Hydraulic Design of Stepped Cascades, Channels, Weirs and Spillways [PDF]

, 1995
Stepped channels and spillways are used since more than 2,500 years. Recently, new construction materials (e.g. RCC, gabions) have increased the interest for stepped chutes.
Hubert Chanson
core  

High‐Speed Video Observations of Recoil Leaders Producing and Not Producing Return Strokes in a Canton‐Tower Upward Flash

Geophysical Research Letters, 2019
High‐speed video and electric field change data have been used to examine the initiation and propagation of 21 recoil leaders, 7 of which evolved into dart (or dart‐stepped) leaders (DLs) initiating return strokes and 14 were attempted leaders (ALs), in ...
Bin Wu, Weitao Lyu, Qi Qi, Ying Ma, Lyuwen Chen, Ruijiao Jiang, Yanan Zhu, Vladimir A. Rakov   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source