Results 51 to 60 of about 11,543 (264)
FLOW RESISTANCE OF STEPPED CHANNEL FLOWS
PROCEEDINGS OF HYDRAULIC ENGINEERING, 2000 Many researchers have investigated the friction factor of stepped channel flows, but general agreement has not been obtained. Because a method for evaluating a supercritical depth of the stepped channel flow might not be established. Further, the hydraulic condition required to form a quasi-uniform flow on the steppedchannel has not been clarified ...
YASUDA, Youichi +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Balanced-to-Balanced Microstrip Diplexer Based on Magnetically Coupled Resonators
IEEE Access, 2018 Two balanced-to-balanced planar diplexers based on magnetically coupled microstrip resonators are proposed in this paper. For the first prototype, each channel/differential-output is composed of a second order single-band balanced bandpass filter based ...
Armando Fernandez-Prieto +5 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
SMART CHANNEL – THE NEXT STEP IN THE EVOLUTION OF MARKETING CHANNELS
International journal of multidisciplinarity in business and scienceThe evolution of marketing channels has progressed from multichannel to omnichannel strategies, driven by advancements in technology and shifting consumer expectations. This paper introduces the concept of the smart channel as the next step in this evolution, enabled by technologies from the Fourth Industrial Revolution (4IR), such as artificial ...
openaire +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Enhancing the discharge capacity of contracted weirs using novel models
Scientific ReportsThis study utilizes three-dimensional Computational Fluid Dynamics simulations to investigate the implementation of stepped and diagonal platforms as a means to enhance the discharge capacity of contracted sharp-crested weirs.
Erdinc Ikinciogullari +2 more
doaj +1 more source
Hydraulics of skimming flows over stepped channels and spillways [PDF]
Journal of Hydraulic Research, 1994 Stepped channel applications include a broad range of domains. A detailed review (past and present) was published by the author (Chanson 1995). To date most studies on gepped chutes applies to gradually variedflows in rectangular prismatic channels with horizontal. The three-dimensional features of stepped chute flows are not accounted.
openaire +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source