Results 91 to 100 of about 11,543 (264)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Hydraulic Capacity of the Segura River Channel (SE Spain) in Urban Areas: 2D Hydraulic Modeling in HEC-RAS and Comparison of Results with the September 2019 Flood Event in the Lower Segura Basin

GeoHazards
This article proposes a novel methodology based on the 2D hydraulic model of the HEC-RAS software, with a stepped ascending hydrograph that allows determining the maximum capacities of the channel (value at which overflow occurs), identifying potential ...
Antonio Oliva, Jorge Olcina
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

AN ENGINEERING APPROACH TO THE STUDY OF THE PROCESSES OF DOUGH FLOW IN THE PRODUCTION OF PASTA AT AGRO-INDUSTRIAL ENTERPRISES

Siberian Journal of Life Sciences and Agriculture
Background. In modern conditions, the provision of domestic pasta produced from durum wheat varieties on modern technological equipment is becoming important.
Anna B. Torgan, Vladimir Ya. Grudanov, Vladimir G. Barsukov, Roza T. Timakova   +3 more
doaj   +1 more source

Dynamic Pressure Fluctuations in Stepped Three-Side Spillway [PDF]

Iranica Journal of Energy and Environment, 2012
One type of outlet works in dams are Three-side spillways that despite of their hydraulic limitations and construction problems, they were being selected, in storage dams, as best option under specific topographical conditions. Considerable energy losses
Hamed Taghizadeh, Seyed Ali Akbar Salehi Neyshabour, Firouz Ghasemzadeh   +2 more
doaj  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Blind Channel Equalization With Algebraic Optimal Step Size

, 2005
Publication in the conference proceedings of EUSIPCO, Antalya, Turkey ...
Vicente Zarzoso, Pierre Comon
openaire   +3 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Multilayered Stub Loaded-SIR for Compact Dual-BPF and Quad-channel Diplexer Design [PDF]

Radioengineering
This paper considers a novel design technique of compact dual-BPF and four-channel diplexer for a multi-service communication system. The suggested dual-band passband filter is constructed by a double-layered stub loaded-stepped impedance resonator (SL ...
S. L. Ajeel, R. T. Hammed
doaj