Results 111 to 120 of about 2,961,303 (350)

A Step-Wedge in the Biochemical Diagnosis of Preeclampsia [PDF]

Clinical Chemistry, 2019
Preeclampsia, a hypertensive disorder of pregnancy, is one of the leading causes of maternal and neonatal morbidity and mortality worldwide. Among the reasons for the great global burden of disease is the poor predictive value of high blood pressure and proteinuria (traditional markers for the disease) for related adverse outcomes (1).
Elizabeth R, Lemoine, S Ananth, Karumanchi   +1 more
openaire   +2 more sources

Rollout trial designs in implementation research are often necessary and sometimes preferred

Implementation Science
Background Rollout designs, which include stepped wedge designs, are defined by staggered implementation of new or alternative programs or services. Critiques of stepped wedge and other rollout designs have raised concerns regarding the confounding of ...
Gregory E. Simon, Bryan R. Garner, Justin D. Smith, Peter A. Wyman, Theresa E. Matson, Lia Chin-Purcell, Ian Cero, Wouter Vermeer, Kimberly A. Johnson, Guillermo Prado, C. Hendricks Brown   +10 more
doaj   +1 more source

Sample size and power analysis for stepped wedge cluster randomised trials with binary outcomes

Statistical Theory and Related Fields, 2021
In stepped wedge cluster randomised trials (SW-CRTs), clusters of subjects are randomly assigned to sequences, where they receive a specific order of treatments.
Jijia Wang, Jing Cao, Song Zhang, Chul Ahn   +3 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The prevention and reduction of weight loss in an acute tertiary care setting: Protocol for a pragmatic stepped wedge randomised cluster trial (the PRoWL Project) [PDF]

, 2013
Background: Malnutrition, with accompanying weight loss, is an unnecessary risk in hospitalised persons and often remains poorly recognised and managed.
A Dickinson, A Jaafar, A Kitson, A Kitson, A Kitson, A Westergren, AC Milne, Age UK, AL Kitson, Alison L Kitson, Alison Shanks, AM Mudge, AM Mudge, Australian Council on Healthcare Standards, C Brown, C Davis, C Liddy, C Mouchoux, C Watterson, C Watterson, C Xia, CA Brown, CA Estabrooks, CA Lamb, CA Russell, D Jefferies, D Moher, D Vanderkroft, DG Duncan, DH Sullivan, DH Sullivan, E Parsons, F Neelemaat, GS Doig, HM Kruizenga, I Boutron, I Boutron, Ian Chapman, J Crosbie, J Kondrup, J Larsson, J Porter, JC Hoekstra, JP McWhirter, K Walton, KE Covinsky, L Bradley, L Brugler, L Villalon, L Wright, Leslye Long, LJ Ross, M Elia, M Elia, M Elia, M Hickson, M Zwarenstein, MA Hussey, MF Tsang, MH Middleton, MK Campbell, N Kagansky, N Laird, National Institute for Health and Clinical Excellence, ND Mdege, R Bailey, R Pawson, R Raja, R Thibault, R Wiechula, Rick Wiechula, RJ Stratton, RJ Stratton, RJ Stratton, RJ Stratton, S Holmes, S Klein, S Naithani, S Wong, SM Green, SM Green, SM Schneider, Stijn Soenen, TF Amaral, Timothy J Schultz, TJ Schultz   +85 more
core   +3 more sources

Impact of decreasing the proportion of higher energy foods and reducing portion sizes on food purchased in worksite cafeterias: A stepped-wedge randomised controlled trial

PLoS Medicine, 2021
Background Overconsumption of energy from food is a major contributor to the high rates of overweight and obesity in many populations. There is growing evidence that interventions that target the food environment may be effective at reducing energy ...
J. Reynolds, M. Ventsel, Daina Kosīte, Brier A Rigby Dames, Laura A. Brocklebank, Sarah Masterton, Emily Pechey, M. Pilling, R. Pechey, G. Hollands, T. Marteau   +10 more
semanticscholar   +1 more source

Designing stepped wedge trials to evaluate physical activity interventions in schools: methodological considerations

International Journal of Behavioral Nutrition and Physical Activity
Background In a stepped wedge design, schools are randomised to a sequence of measurements, with each sequence transitioning to intervention status at a different time.
Ruth Salway, Danielle House, Simona Kent-Saisch, Robert Walker, Lydia Emm-Collison, Alice Porter, David R Lubans, Michael Beets, Frank de Vocht, Russell Jago   +9 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Generalizing the information content for stepped wedge designs: A marginal modeling approach

Scandinavian journal of statistics, theory and applications, 2022
Stepped wedge trials are increasingly adopted because practical constraints necessitate staggered roll‐out. While a complete design requires clusters to collect data in all periods, resource and patient‐centered considerations may call for an incomplete ...
Fan Li, J. Kasza, E. Turner, P. Rathouz, A. Forbes, J. Preisser   +5 more
semanticscholar   +1 more source

Effect and associated factors of a clinical pharmacy model in the incidence of medication errors (EACPharModel) in the Hospital Pablo Tobón Uribe: study protocol for a stepped wedge randomized controlled trial (NCT03338725)

Trials, 2020
Background According to WHO, medication error (ME) is a subject that requires attention at all levels of care to reduce severe and preventable damage related to medication use.
J. Granados, A. Salazar-Ospina, J. P. Botero-Aguirre, A. F. Valencia-Quintero, N. Ortiz, P. Amariles   +5 more
doaj   +1 more source