Results 131 to 140 of about 2,961,303 (350)

Stepped wedge cluster randomized controlled trials: sample size and power determinations [PDF]

open access: yes, 2014
Stepped wedge cluster randomized controlled trials (RCTs) are increasingly used in evaluating a causal-effect relationship between an intervention and an outcome. Sample size and power calculations are critical in designing a statistical study. Thus, the
Chen, Hsiang-Yu
core  

Ethnolinguistic concordance and the receipt of postpartum IUD counseling services in Sri Lanka. [PDF]

open access: yes, 2018
CONTEXT: Ethnic and linguistic concordance are important dimensions of the patient-physician relationship, and are linked to health care disparities.
Canning, David   +5 more
core   +1 more source

Comparison of analysis methods and design choices for treatment-by-period interaction in unidirectional switch designs: a simulation study

open access: yesBMC Medical Research Methodology, 2022
Background Due to identifiability problems, statistical inference about treatment-by-period interactions has not been discussed for stepped wedge designs in the literature thus far.
Zhuozhao Zhan   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Multilevel Intervention Stepped Wedge Designs (MLI-SWDs)

open access: yesPrevention Science
AbstractMultilevel interventions (MLIs) hold promise for reducing health inequities by intervening at multiple types of social determinants of health consistent with the socioecological model of health. In spite of their potential, methodological challenges related to study design compounded by a lack of tools for sample size calculation inhibit their ...
Linnan, Laura   +3 more
openaire   +2 more sources

Permutation tests for stepped-wedge cluster-randomized trials [PDF]

open access: yesThe Stata Journal: Promoting communications on statistics and Stata, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the permute command does not produce valid tests in this setting because individual observations are not exchangeable. We introduce the swpermute command, which permutes clusters to sequences to maintain exchangeability ...
Jennifer Thompson   +4 more
openaire   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Feasibility of a theory-based intervention to reduce sedentary behaviour among contact centre staff: the SUH stepped-wedge cluster RCT

open access: yesPublic Health Research, 2022
Background: Sedentary behaviour is linked to increased risk of type 2 diabetes, cardiovascular disease, musculoskeletal issues and poor mental well-being.
Ruth Jepson   +6 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting

open access: yesBritish medical journal, 2015
The stepped wedge cluster randomised trial is a novel research study design that is increasingly being used in the evaluation of service delivery type interventions.
K. Hemming   +4 more
semanticscholar   +1 more source

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