Results 151 to 160 of about 2,961,303 (350)

Longitudinal exploration of the delivery of care following a successful antenatal practice change intervention

Frontiers in Medicine
IntroductionThis is a secondary analysis of a stepped-wedge trial. The sustainment of evidence-based care is essential for ongoing population benefits.
Alix Hall, Alix Hall, Alix Hall, Emma Doherty, Emma Doherty, Emma Doherty, Nicole Nathan, Nicole Nathan, Nicole Nathan, John Wiggers, John Wiggers, John Wiggers, John Attia, John Attia, Belinda Tully, Belinda Tully, Belinda Tully, Elizabeth J. Elliott, Elizabeth J. Elliott, Christopher Oldmeadow, Christopher Oldmeadow, Simon Chiu, Simon Chiu, Melanie Kingsland, Melanie Kingsland, Melanie Kingsland   +25 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Predictive risk stratification model: a randomised stepped-wedge trial in primary care (PRISMATIC)

Health Services and Delivery Research, 2018
Background: With a higher proportion of older people in the UK population, new approaches are needed to reduce emergency hospital admissions, thereby shifting care delivery out of hospital when possible and safe.
Helen Snooks, Kerry Bailey-Jones, Deborah Burge-Jones, Jeremy Dale, Jan Davies, Bridie Evans, Angela Farr, Deborah Fitzsimmons, Jane Harrison, Martin Heaven, Helen Howson, Hayley Hutchings, Gareth John, Mark Kingston, Leo Lewis, Ceri Phillips, Alison Porter, Bernadette Sewell, Daniel Warm, Alan Watkins, Shirley Whitman, Victoria Williams, Ian T Russell   +22 more
doaj   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Explaining negative refraction without negative refractive indices

, 2017
Negative refraction through a triangular prism may be explained without assigning a negative refractive index to the prism by using array theory. For the case of a beam incident upon the wedge, the array theory accurately predicts the beam transmission ...
Garner, Timothy J., Talalai, Gregory A., Weiss, Steven J.   +2 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

An Integrated-Photonics Optical-Frequency Synthesizer

, 2017
Integrated-photonics microchips now enable a range of advanced functionalities for high-coherence applications such as data transmission, highly optimized physical sensors, and harnessing quantum states, but with cost, efficiency, and portability much ...
A Bluestone, AA Savchenkov, Aaron Bluestone, B. Robert Ilic, Connor Fredrick, Daron Westly, Daryl T. Spencer, DC Cole, DJ Moss, Dong Yoon Oh, Erik Norberg, F Ferdous, FR Giorgetta, G Ycas, IS Grudinin, J Li, JD Jost, JD Jost, JL Hall, JL O’Brien, John E. Bowers, Jordan Stone, Kartik Srinivasan, Kerry Vahala, Ki Youl Yang, L Chang, Laura C. Sinclair, LC Sinclair, Lin Chang, Luke Theogarajan, Martin H. P. Pfeiffer, MHP Pfeiffer, Myoung-Gyun Suh, N Volet, Nathan R. Newbury, Nicolas Volet, P Del’Haye, P Del’Haye, P Del’Haye, P Del’Haye, Q Li, Qing Li, S Arafin, S Arafin, S Coen, S Rumley, S Srinivasan, SB Papp, SB Papp, Scott A. Diddams, Scott B. Papp, Seung Hoon Lee, T Herr, T Komljenovic, T Komljenovic, Tara Drake, Tin Komljenovic, TJ Kippenberg, Tobias J. Kippenberg, TP Purdy, Travis C. Briles, TW Hänsch, V Brasch, V Brasch, X Yi, Y Okawachi   +65 more
core   +1 more source