Results 101 to 110 of about 90,354 (334)

The current use of feasibility studies in the assessment of feasibility for stepped-wedge cluster randomised trials: a systematic review

BMC Medical Research Methodology, 2019
Background Stepped-wedge cluster randomised trials (SW-CRTs) are a pragmatic trial design, providing an unprecedented opportunity to increase the robustness of evidence underpinning implementation and quality improvement interventions.
Caroline A. Kristunas, Karla Hemming, Helen Eborall, Sandra Eldridge, Laura J. Gray   +4 more
doaj   +1 more source

The impact of the Trauma Triage App on pre-hospital trauma triage: design and protocol of the stepped-wedge, cluster-randomized TESLA trial

Diagnostic and Prognostic Research, 2020
Background Field triage of trauma patients is crucial to get the right patient to the right hospital within a particular time frame. Minimization of undertriage, overtriage, and interhospital transfer rates could substantially reduce mortality rates ...
Rogier van der Sluijs, Audrey A. A. Fiddelers, Job F. Waalwijk, Johannes B. Reitsma, Miranda J. Dirx, Dennis den Hartog, Silvia M. A. A. Evers, J. Carel Goslings, W. Margreet Hoogeveen, Koen W. Lansink, Luke P. H. Leenen, Mark van Heijl, Martijn Poeze   +12 more
doaj   +1 more source

Evaluation of multiple interventions using a stepped wedge design [PDF]

, 2017
Background: Stepped wedge cluster randomized trials are a class of unidirectional crossover studies that have historically been limited to evaluating a single intervention.
Hughes, James, Li, Lingyu, Lyons, Vivian H, Rowhani-Rahbar, Ali   +3 more
core   +1 more source

Randomised controlled trials of complex interventions and large-scale transformation of services [PDF]

, 2016
Complex interventions and large-scale transformations of services are necessary to meet the health-care challenges of the 21st century. However, the evaluation of these types of interventions is challenging and requires methodological development ...
Barratt, Helen, Bower, Peter, Campbell, Marion, Moore, Laurence, Zwarenstein, Merrick   +4 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial

BMC Public Health, 2023
Background Tuberculosis(TB) is among the leading causes of infectious death worldwide. Contact investigation is an evidence-based, World Health Organisation-endorsed intervention for timely TB diagnosis, treatment, and prevention but has not been widely ...
Achilles Katamba, Amanda J Gupta, Patricia Turimumahoro, Emmanuel Ochom, Joseph M Ggita, Suzan Nakasendwa, Leah Nanziri, Johnson Musinguzi, Rachel Hennein, Moorine Sekadde, Colleen Hanrahan, Raymond Byaruhanga, Erez Yoeli, Stavia Turyahabwe, Adithya Cattamanchi, David W Dowdy, Jessica E Haberer, Mari Armstrong-Hough, Noah Kiwanuka, J. Lucian Davis   +19 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Can using the functional resonance analysis method, as an intervention, improve patient safety in hospitals?: a stepped wedge design protocol

BMC Health Services Research, 2021
Background Healthcare professionals are sometimes forced to adjust their work to varying conditions leading to discrepancies between hospital protocols and daily practice. We will examine the discrepancies between protocols, ‘Work As Imagined’ (WAI), and
Liselotte M. van Dijk, Meggie D. Meulman, Linda van Eikenhorst, Hanneke Merten, Bernadette C. F. M. Schutijser, Cordula Wagner   +5 more
doaj   +1 more source

Methodological progress note: Stepped‐wedge cluster randomized trial design

Journal of Hospital Medicine
Hospitalists are often involved in quality and research efforts to improve care delivery in the inpatient setting.1 To assess the effectiveness of these efforts, new healthcare delivery initiatives may be evaluated by comparing clinical outcomes between patients who received the intervention and those who received usual care, which is commonly used as ...
Alina G. Burek, Amanda Ullman, David C. Brousseau   +2 more
openaire   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source