Results 111 to 120 of about 99,537 (336)
BMC Public Health, 2023 Background Tuberculosis(TB) is among the leading causes of infectious death worldwide. Contact investigation is an evidence-based, World Health Organisation-endorsed intervention for timely TB diagnosis, treatment, and prevention but has not been widely ...
Achilles Katamba +19 more
doaj +1 more source
The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting [PDF]
BMJ, 2015 The stepped wedge cluster randomised trial is a novel research study design that is increasingly being used in the evaluation of service delivery type interventions. The design involves random and sequential crossover of clusters from control to intervention until all clusters are exposed. It is a pragmatic study design which can reconcile the need for
K, Hemming +4 more
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
BMC Health Services Research, 2021 Background Healthcare professionals are sometimes forced to adjust their work to varying conditions leading to discrepancies between hospital protocols and daily practice. We will examine the discrepancies between protocols, ‘Work As Imagined’ (WAI), and
Liselotte M. van Dijk +5 more
doaj +1 more source
Novel methods for the analysis of stepped wedge cluster randomized trials
Statistics in Medicine, 2019 Stepped wedge cluster randomized trials (SW‐CRTs) have become increasingly popular and are used for a variety of interventions and outcomes, often chosen for their feasibility advantages. SW‐CRTs must account for time trends in the outcome because of the staggered rollout of the intervention.
Lee Kennedy‐Shaffer +2 more
openaire +4 more sources
Hospital-wide Rollout of Antimicrobial Stewardship: A Stepped-Wedge Randomized Trial [PDF]
Clinical Infectious Diseases, 2014 Our objective was to rigorously evaluate the impact of an antimicrobial stewardship audit-and-feedback intervention, via a stepped-wedge randomized trial. An effective intensive care unit (ICU) audit-and-feedback program was rolled out to 6 non-ICU services in a randomized sequence.
Lesley, Palmay +9 more
openaire +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Frontiers in MedicineIntroductionThis is a secondary analysis of a stepped-wedge trial. The sustainment of evidence-based care is essential for ongoing population benefits.
Alix Hall +25 more
doaj +1 more source
Examining evidence based resistance plus balance training in community-dwelling older adults with complex health care needs: Trial protocol for the Muscling Up Against Disability project [PDF]
, 2017 Available online 6 October 2016Abstract not availableJustin W.L.
Gardiner, Paul +5 more
core +2 more sources
Implementation Science, 2019 BackgroundNational leaders recommend documenting social determinants of health and actions taken to address social determinants of health in electronic health records, and a growing body of evidence suggests the health benefits of doing so.
Rachel Gold +15 more
semanticscholar +1 more source