Results 121 to 130 of about 90,354 (334)

Evaluation of interventions to prevent vasovagal reactions among whole blood donors: rationale and design of a large cluster randomised trial

Trials, 2023
Background Vasovagal reactions (VVRs) are the most common acute complications of blood donation. Responsible for substantial morbidity, they also reduce the likelihood of repeated donations and are disruptive and costly for blood services. Although blood
Amy McMahon, Stephen Kaptoge, Matthew Walker, Susan Mehenny, Philippe T Gilchrist, Jennifer Sambrook, Naim Akhtar, Michael Sweeting, Angela M Wood, Kathleen Stirrups, Ryan Chung, Sarah Fahle, Elisha Johnson, Donna Cullen, Rosemary Godfrey, Shannon Duthie, Louise Allen, Paul Harvey, Michael Berkson, Elizabeth Allen, Nicholas A Watkins, John R Bradley, Nathalie Kingston, Gail Miflin, Jane Armitage, David J Roberts, John Danesh, Emanuele Di Angelantonio   +27 more
doaj   +1 more source

Sample Size Calculation for an Individual Stepped‐Wedge Randomized Trial

Biometrical Journal
ABSTRACTIn the individual stepped‐wedge randomized trial (ISW‐RT), subjects are allocated to sequences, each sequence being defined by a control period followed by an experimental period. The total follow‐up time is the same for all sequences, but the duration of the control and experimental periods varies among sequences. To our knowledge, there is no
Allemang-Trivalle, Aude, Maruani, Annabel, Giraudeau, Bruno   +2 more
openaire   +5 more sources

Stepped wedge trials with continuous recruitment require new ways of thinking [PDF]

Journal of Clinical Epidemiology, 2019
There is substantial variation in the design of stepped wedge trials. Many recruit participants continuously over time, although the methodological literature has tended not to differentiate closely between continuous recruitment and discrete sampling.
Hooper, R, Copas, A
openaire   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Designing stepped wedge trials to evaluate physical activity interventions in schools: methodological considerations

International Journal of Behavioral Nutrition and Physical Activity
Background In a stepped wedge design, schools are randomised to a sequence of measurements, with each sequence transitioning to intervention status at a different time.
Ruth Salway, Danielle House, Simona Kent-Saisch, Robert Walker, Lydia Emm-Collison, Alice Porter, David R Lubans, Michael Beets, Frank de Vocht, Russell Jago   +9 more
doaj   +1 more source

Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): study protocol for a randomised, stepped-wedge cluster trial within the EFFECTS trial

Trials, 2018
Background Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery.
Erik Lundström, Eva Isaksson, Per Wester, Ann-Charlotte Laska, Per Näsman   +4 more
doaj   +1 more source

Stepped wedge cluster randomised trials: a review of the statistical methodology used and available [PDF]

, 2016
Background: Previous reviews have focussed on the rationale for employing the stepped wedge design (SWD), the areas of research to which the design has been applied and the general characteristics of the design.
Barker, D., Campbell, M.J., D’Este, C., McElduff, P.   +3 more
core   +3 more sources

Increasing the capacity of policy agencies to use research findings: a stepped-wedge trial

Health Research Policy and Systems, 2019
BackgroundThis paper describes the trial of a novel intervention, Supporting Policy In health with evidence from Research: an Intervention Trial (SPIRIT).
A. Williamson, Daniel Barker, Sally E. Green, C. D’Este, H. Davies, Louisa R Jorm, A. Shakeshaft, Sian Rudge, S. Redman   +8 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Promoting Recruitment using Information Management Efficiently (PRIME): study protocol for a stepped wedge cluster randomised controlled trial within the REstart or STop Antithrombotics Randomised Trial (RESTART) [PDF]

, 2017
BACKGROUND: Research into methods to boost recruitment has been identified as the highest priority for randomised controlled trial (RCT) methodological research in the United Kingdom.
Dennis, Martin, Maxwell, Amy, Parker, Richard, Rudd, Anthony, Salman, Rustam, Weir, Christopher   +5 more
core   +1 more source