Results 131 to 140 of about 99,537 (336)

Increasing the capacity of policy agencies to use research findings: a stepped-wedge trial

Health Research Policy and Systems, 2019
BackgroundThis paper describes the trial of a novel intervention, Supporting Policy In health with evidence from Research: an Intervention Trial (SPIRIT).
A. Williamson, Daniel Barker, Sally E. Green, C. D’Este, H. Davies, Louisa R Jorm, A. Shakeshaft, Sian Rudge, S. Redman   +8 more
semanticscholar   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Stepped wedge cluster randomized controlled trial designs: a review of reporting quality and design features [PDF]

, 2017
Background The stepped wedge (SW) cluster randomized controlled trial (CRCT) design is being used with increasing frequency. However, there is limited published research on the quality of reporting of SW-CRCTs.
Grayling, Michael J, Wason, James M S, Mander, Adrian P   +2 more
core   +1 more source

SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia

BMJ Open, 2019
Introduction Skin is important in Australian Aboriginal culture informing kinship and identity. In many remote Aboriginal communities, scabies and impetigo are very common.
M. Mullane, T. C. Barnett, J. Cannon, J. Carapetis, Ray Christophers, J. Coffin, Mark A Jones, J. Marsh, Frieda Mc Loughlin, Vicki O'Donnell, R. Pavlos, Bec Smith, A. Steer, S. Tong, R. Walker, A. Bowen   +15 more
semanticscholar   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The use of permutation tests for the analysis of parallel and stepped-wedge cluster randomized trials [PDF]

, 2016
We investigate the use of permutation tests for the analysis of parallel and stepped-wedge cluster randomized trials. Permutation tests for parallel designs with exponential family endpoints have been extensively studied.
DeGruttola, Victor, Wang, Rui
core   +1 more source

Sedation AND Weaning In Children (SANDWICH): protocol for a cluster randomised stepped wedge trial

BMJ Open, 2019
Introduction Weaning from ventilation is a complex process involving several stages that include recognition of patient readiness to begin the weaning process, steps to reduce ventilation while optimising sedation in order not to induce distress and ...
B. Blackwood, A. Agus, Roisin Boyle, M. Clarke, K. Hemming, J. Jordan, D. Macrae, D. McAuley, C. McDowell, L. McIlmurray, K. Morris, Margaret Murray, R. Parslow, M. Peters, L. Tume, T. Walsh   +15 more
semanticscholar   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Reporting quality of stepped wedge design randomized trials: a systematic review protocol

Clinical Epidemiology, 2016
Alex Thabane,1,2 Brittany B Dennis,3,4 Olga Gajic-Veljanoski,3,9,10 James Paul,2,3 Lehana Thabane2,3,5-8 1Life Sciences Program, Queen’s University, Kingston, ON, Canada; 2Department of Anesthesia, McMaster University Hamilton ON, 3Department of ...
Thabane A, Dennis BB, Gajic-Veljanoski O, Paul J, Thabane L   +4 more
doaj  

The hunt for efficient, incomplete designs for stepped wedge trials with continuous recruitment and continuous outcome measures

BMC Medical Research Methodology, 2020
Background We consider the design of stepped wedge trials with continuous recruitment and continuous outcome measures. Suppose we recruit from a fixed number of clusters where eligible participants present continuously, and suppose we have fine control ...
Richard Hooper, Jessica Kasza, Andrew Forbes   +2 more
doaj   +1 more source