Results 131 to 140 of about 90,354 (334)

SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia

BMJ Open, 2019
Introduction Skin is important in Australian Aboriginal culture informing kinship and identity. In many remote Aboriginal communities, scabies and impetigo are very common.
M. Mullane, T. C. Barnett, J. Cannon, J. Carapetis, Ray Christophers, J. Coffin, Mark A Jones, J. Marsh, Frieda Mc Loughlin, Vicki O'Donnell, R. Pavlos, Bec Smith, A. Steer, S. Tong, R. Walker, A. Bowen   +15 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The hunt for efficient, incomplete designs for stepped wedge trials with continuous recruitment and continuous outcome measures

BMC Medical Research Methodology, 2020
Background We consider the design of stepped wedge trials with continuous recruitment and continuous outcome measures. Suppose we recruit from a fixed number of clusters where eligible participants present continuously, and suppose we have fine control ...
Richard Hooper, Jessica Kasza, Andrew Forbes   +2 more
doaj   +1 more source

The use of permutation tests for the analysis of parallel and stepped-wedge cluster randomized trials [PDF]

, 2016
We investigate the use of permutation tests for the analysis of parallel and stepped-wedge cluster randomized trials. Permutation tests for parallel designs with exponential family endpoints have been extensively studied.
DeGruttola, Victor, Wang, Rui
core   +1 more source

Stepped wedge cluster randomized controlled trial designs: a review of reporting quality and design features [PDF]

, 2017
Background The stepped wedge (SW) cluster randomized controlled trial (CRCT) design is being used with increasing frequency. However, there is limited published research on the quality of reporting of SW-CRCTs.
Grayling, Michael J, Wason, James M S, Mander, Adrian P   +2 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Stepped-wedge cluster randomised controlled trials : a generic framework including parallel and multiple-level designs [PDF]

, 2014
Stepped-wedge cluster randomised trials (SW-CRTs) are being used with increasing frequency in health service evaluation. Conventionally, these studies are cross-sectional in design with equally spaced steps, with an equal number of clusters randomised at
Girling, Alan J., Hemming, Karla, Lilford, Richard   +2 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Reporting quality of stepped wedge design randomized trials: a systematic review protocol

Clinical Epidemiology, 2016
Alex Thabane,1,2 Brittany B Dennis,3,4 Olga Gajic-Veljanoski,3,9,10 James Paul,2,3 Lehana Thabane2,3,5-8 1Life Sciences Program, Queen’s University, Kingston, ON, Canada; 2Department of Anesthesia, McMaster University Hamilton ON, 3Department of ...
Thabane A, Dennis BB, Gajic-Veljanoski O, Paul J, Thabane L   +4 more
doaj  

Design of the HIV Prevention Trials Network (HPTN) Protocol 054: A cluster randomized crossover trial to evaluate combined access to Nevirapine in developing countries [PDF]

, 2003
HPTN054 is a cluster randomized trial designed to compare two approaches to providing single dose nevirapine to HIV-seropositive mothers and their infants to prevent mother-to-child transmission of HIV in resource limited settings.
Goldenberg, Robert L., Guay, Laura A., Hughes, Jim, Mmiro, Francis, Mwinga, Kasonde G., Stringer, Jeffrey S. A., Valentine, Megan, Wilfert, Catherine M.   +7 more
core   +1 more source