Results 141 to 150 of about 90,354 (334)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Leveraging Contact Network Structure in the Design of Cluster Randomized Trials [PDF]

, 2016
Background: In settings like the Ebola epidemic, where proof-of-principle trials have succeeded but questions remain about the effectiveness of different possible modes of implementation, it may be useful to develop trials that not only generate ...
DeGruttola, Victor, Harling, Guy, Onnela, Jukka-Pekka, Wang, Rui   +3 more
core   +3 more sources

Sedation AND Weaning In Children (SANDWICH): protocol for a cluster randomised stepped wedge trial

BMJ Open, 2019
Introduction Weaning from ventilation is a complex process involving several stages that include recognition of patient readiness to begin the weaning process, steps to reduce ventilation while optimising sedation in order not to induce distress and ...
B. Blackwood, A. Agus, Roisin Boyle, M. Clarke, K. Hemming, J. Jordan, D. Macrae, D. McAuley, C. McDowell, L. McIlmurray, K. Morris, Margaret Murray, R. Parslow, M. Peters, L. Tume, T. Walsh   +15 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The reporting quality of abstracts of stepped wedge randomized trials is suboptimal: A systematic survey of the literature

Contemporary Clinical Trials Communications, 2017
Background: The stepped wedge trial (SWT) design is a type of the randomized clinical trial (RCT) design in which clusters or individuals are randomly and sequentially crossed over from control to intervention over a number of time periods.
Mei Wang, Yanling Jin, Zheng Jing Hu, Alex Thabane, Brittany Dennis, Olga Gajic-Veljanoski, James Paul, Lehana Thabane   +7 more
doaj   +1 more source

The effect of a complementary e-learning course on implementation of a quality improvement project regarding care for elderly patients: a stepped wedge trial [PDF]

, 2012
Background Delirium occurs frequently in elderly hospitalised patients and is associated with higher mortality, increased length of hospital stay, functional decline, and admission to long-term care.
CA Brown, Cordula Wagner, D Anderson, DA Cook, EJ Thomas, ER Marcantonio, HM Kruizenga, J McCusker, J Witlox, JG Bloomfield, K Irving, LA van Gemert, LH Moulton, Lotte Van de Steeg, M Abdolrasulnia, M Agar, M Zegers, MA Hussey, Maaike Langelaan, MC de Bruijne, ME Charlson, MG Cole, MJ Schuurmans, MJ Schuurmans, MT Vidán, N Steverink, N Tabet, ND Mdege, RJ Stratton, Roelie Ijkema, S Katz, SK Inouye, SK Inouye, SK Inouye, SK Inouye, V Mittal   +35 more
core   +4 more sources

Stroke Ready: a multi-level program that combines implementation science and community-based participatory research approaches to increase acute stroke treatment: protocol for a stepped wedge trial

Implementation Science, 2019
BackgroundPost-stroke disability is common, costly, and projected to increase. Acute stroke treatments can substantially reduce post-stroke disability, but few patients take advantage of these cost-effective treatments.
Lesli E. Skolarus, Anne Sales, Marc A. Zimmerman, Casey L. Corches, Zach Landis-Lewis, Maria Cielito Robles, A. McBride, Narmeen Rehman, Alina Oliver, Nishat Islam, Mellanie V. Springer, O. Alison, Brien, Sarah Bailey, Lewis B. Morgenstern, William Meurer, James F Burke   +16 more
semanticscholar   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

DIZZiness treatment through implementation and clinical strategy Tactics-2 (DIZZTINCT-2) project—a clinical trial protocol

Trials
Background The evaluation and management of acute vertigo presentations is challenging for both patients and physicians. Benign paroxysmal positional vertigo (BPPV), acute unilateral vestibulopathy (e.g., vestibular neuritis), and stroke are priority ...
William J. Meurer, Stacy Park, Huong Nguyen, Silvia R. Paz, Molly O. Jancis, Julliane Bacerdo, Aileen S. Baecker, Prasanth Manthena, Navdeep S. Sangha, Chengyi Zheng, Lawrence C. An, Terry D. Fife, Adam L. Sharp, James F. Burke, Kevin A. Kerber   +14 more
doaj   +1 more source

Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations [PDF]

, 2017
Health care-associated infections (HAI) are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide.
A Higgins, A Jamal, A Lipitz-Snyderman, A Pinto, AF Vicca, AJ Howie, AM Yinnon, AR Marra, AS Mathai, B Allegranzi, BA Mark, BN Reames, BS Koll, BW Thomas, C Brandt, C Fuller, CS Cocanour, D Fisher, D Pittet, D Pittet, D Quiros, DD Wirtschafter, DG Bundy, DJ Birnbach, DM Henderson, E Creamer, Effective Practice and Organisation of Care (EPOC), EG Shepherd, EL Geubbels, EL Larson, F L’Heriteau, F Schwab, G Pontivivo, GB Allen, GH Guyatt, HW Kilbride, I Zuschneid, International Health Regulations, J Alonso-Echanove, J Bion, J Blatnik, J Mayer, J Robert, JA Al-Tawfiq, JA Marsteller, JB Cunningham, JB Cunningham, JB Cunningham, JH Barsuk, JH Jang, JJ Anderson, JW Lederer Jr, KB Kirkland, KB Stevenson, L Bouadma, L Charrier, L Gerolemou, L Johnson, L Rubinson, LA Mermel, LJ Damschroder, LL McKinley, M Thomas, M Virtanen, M Whitby, MA Borg, MA Borg, MD Koff, ML Grayson, ML McLaws, ML McLaws, ML Render, ML Schweizer, MR Miller, MR Miller, N Petrosillo, P Eggimann, P Gastmeier, P Gastmeier, P Gastmeier, P Gastmeier, PW Nicol, R Jain, R Peredo, RJ Sherertz, RM Sladek, RW Haley, S Barwolff, S Hansen, S Hugonnet, S Hugonnet, S Hugonnet, S Newitt, S Nijssen, SA Creedon, SC Joshi, SI Doron, SK Fridkin, SM Brown, SR Lieber, TR Talbot, V Rodriguez, VA DePalo, VD Rosenthal, VD Rosenthal, VD Rosenthal, VD Rosenthal, W Moongtui, W Turnberg, W Zingg, W Zingg, W Zingg, WN Viana, YL Kwok   +113 more
core   +6 more sources