Results 151 to 160 of about 90,354 (334)

Assessing Mediation in Cross‐Sectional Stepped Wedge Cluster Randomized Trials

Statistics in Medicine
ABSTRACT Mediation analysis has been studied for independent data, but relatively little work has been done for correlated data observed under stepped wedge cluster randomized trials (SW‐CRTs). Motivated by the need to understand the effect mechanisms in SW‐CRTs, we develop a set of regression‐based methods for ...
Zhiqiang Cao, Fan Li
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Overcoming challenges in real‐world evidence generation: An example from an Adult Medical Care Coordination program

Learning Health Systems
The Adult Medical Care Coordination program (“the program”) was implemented at Mayo Clinic to promote patient self‐management and improve 30‐day unplanned readmission for patients with high risk for readmission after hospital discharge.
Samuel T. Savitz, Michelle A. Lampman, Shealeigh A. Inselman, Ruchita Dholakia, Vicki L. Hunt, Angela B. Mattson, Robert J. Stroebel, Pamela J. McCabe, Stephanie G. Witwer, Bijan J. Borah   +9 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Reducing Medical Admissions into Hospital through Optimising Medicines (REMAIN HOME) Study: Protocol for a stepped wedge, cluster randomised trial [PDF]

, 2017
Introduction: A model of general practitioner (GP) and pharmacist collaboration in primary care may be an effective strategy to reduce medication-related problems and provide better support to patients after discharge.
Arnold, Australian Council on Safety and Quality in Health Care, Belleli, Bonnet-Zamponi, Campbell, Campbell, Chan, Coleman, Davies, Freeman, Freeman, Hansen, Hawes, Hazen, Hemming, Hemming, Holland, Howell, Hussey, Independent Hospital Pricing Authority, Independent Hospital Pricing Authority, Jack, Jencks, Kilcup, Kwan, Leppin, Mekonnen, Mueller, Naunton, Pal, Picker, Polinski, Rockwood, Stowasser, Tan, Tedesco, Unroe, Van, Vashi, Williams, Wimmer   +40 more
core   +1 more source

Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial

Orphanet Journal of Rare Diseases, 2018
BackgroundRett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of the effects of impaired MECP2 function is reduced production of Brain Derived Neurotrophic Factor (BDNF), a ...
J. Downs, J. Rodger, Chen Li, Xuesong Tan, Nan Hu, Kingsley Wong, N. de Klerk, H. Leonard   +7 more
semanticscholar   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The Devon Active Villages Evaluation (DAVE) trial: study protocol of a stepped wedge cluster randomised trial of a community-level physical activity intervention in rural southwest England [PDF]

, 2012
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Although physical inactivity has been linked with numerous chronic health conditions and overall ...
Hillsdon, Melvyn, Metcalf, B, Rees, Tim, Solomon, Emma, Ukoumunne, Obioha C.   +4 more
core   +2 more sources

Implementing Systematic Screening and Structured Care for Distressed Callers Using Cancer Council’s Telephone Services: Protocol for a Randomized Stepped-Wedge Trial

JMIR Research Protocols, 2019
Background Structured distress management, comprised a 2-stage screening and referral model, can direct supportive care resources toward individuals who are most likely to benefit.
E. Fradgley, A. Boltong, Lorna O'Brien, Allison Boyes, Katherine Lane, Annette Beattie, Tara Clinton-McHarg, Paul B Jacobsen, Christopher M. Doran, Daniel Barker, Della Roach, Jo Taylor, C. Paul   +12 more
semanticscholar   +1 more source

swpermute: Permutation tests for Stepped-Wedge Cluster-Randomised Trials. [PDF]

The Stata journal, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the Stata command permute does not produce valid tests in this setting because individual observations are not exchangeable.
Thompson, Jennifer, Davey, Calum, Hayes, Richard, Hargreaves, James, Fielding, Katherine   +4 more
openaire   +1 more source