Results 151 to 160 of about 99,537 (336)

Crowdsourcing to promote HIV testing among MSM in China: study protocol for a stepped wedge randomized controlled trial. [PDF]

, 2017
BACKGROUND: HIV testing for marginalized populations is critical to controlling the HIV epidemic. However, the HIV testing rate among men who have sex with men (MSM) in China remains low. Crowdsourcing, the process of shifting individual tasks to a group,
SESH Study Group, Tucker, Joseph D
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Improving access for community health and sub-acute outpatient services: protocol for a stepped wedge cluster randomised controlled trial [PDF]

, 2016
BACKGROUND: Waiting lists for treatment are common in outpatient and community services, Existing methods for managing access and triage to these services can lead to inequities in service delivery, inefficiencies and divert resources from frontline care.
AD MacCormick, BR Holroyd, Bridie Kent, C Brown, C Fogarty, D Goldstein, DF Hamilton, G Lynch, J Richardson, J Rycroft-Malone, J Terris, Jackie Kearney, JC Brillman, Jennifer J. Watts, K Harding, Katherine E. Harding, KE Harding, KE Harding, KE Harding, KE Harding, KL Russell, KV Iserson, L Grilli, Leila Karimi, M Hussey, M Murray, M Murray, Mary O’Reilly, ME Lynch, Michelle Kotis, Nicholas F. Taylor, P Kenis, R Davies, R Tideman, S Fernandez, S Walters, SA Kreindler, Sandra G. Leggat, W Woertman   +38 more
core   +2 more sources

Stroke Ready: a multi-level program that combines implementation science and community-based participatory research approaches to increase acute stroke treatment: protocol for a stepped wedge trial

Implementation Science, 2019
BackgroundPost-stroke disability is common, costly, and projected to increase. Acute stroke treatments can substantially reduce post-stroke disability, but few patients take advantage of these cost-effective treatments.
Lesli E. Skolarus, Anne Sales, Marc A. Zimmerman, Casey L. Corches, Zach Landis-Lewis, Maria Cielito Robles, A. McBride, Narmeen Rehman, Alina Oliver, Nishat Islam, Mellanie V. Springer, O. Alison, Brien, Sarah Bailey, Lewis B. Morgenstern, William Meurer, James F Burke   +16 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The reporting quality of abstracts of stepped wedge randomized trials is suboptimal: A systematic survey of the literature

Contemporary Clinical Trials Communications, 2017
Background: The stepped wedge trial (SWT) design is a type of the randomized clinical trial (RCT) design in which clusters or individuals are randomly and sequentially crossed over from control to intervention over a number of time periods.
Mei Wang, Yanling Jin, Zheng Jing Hu, Alex Thabane, Brittany Dennis, Olga Gajic-Veljanoski, James Paul, Lehana Thabane   +7 more
doaj   +1 more source

The Devon Active Villages Evaluation (DAVE) trial: study protocol of a stepped wedge cluster randomised trial of a community-level physical activity intervention in rural southwest England [PDF]

, 2012
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Although physical inactivity has been linked with numerous chronic health conditions and overall ...
Hillsdon, Melvyn, Metcalf, B, Rees, Tim, Solomon, Emma, Ukoumunne, Obioha C.   +4 more
core   +2 more sources

swpermute: Permutation tests for Stepped-Wedge Cluster-Randomised Trials. [PDF]

The Stata journal, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the Stata command permute does not produce valid tests in this setting because individual observations are not exchangeable.
Thompson, Jennifer, Davey, Calum, Hayes, Richard, Hargreaves, James, Fielding, Katherine   +4 more
openaire   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial

Orphanet Journal of Rare Diseases, 2018
BackgroundRett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of the effects of impaired MECP2 function is reduced production of Brain Derived Neurotrophic Factor (BDNF), a ...
J. Downs, J. Rodger, Chen Li, Xuesong Tan, Nan Hu, Kingsley Wong, N. de Klerk, H. Leonard   +7 more
semanticscholar   +1 more source