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Analysis of Data from a Stepped Wedge Trial

Analysis of Data from Randomized Controlled Trials, 2021
In this chapter the different methods for the analysis of data from a stepped wedge trial are discussed. These methods contain the comparison of different arms, the comparison of groups with a different number of intervention measurement, and the comparison of transitions.
J. Twisk
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What Is a Stepped-Wedge Cluster Randomized Trial?

JAMA Internal Medicine
This Guide to Statistics and Methods describes design, interpretation, and examples of a stepped-wedge cluster randomized trial.
Fan Li, Bingkai Wang, P. Heagerty
semanticscholar   +3 more sources

Stepped Wedge Cluster Randomized Trials: A Methodological Overview

World Neurosurgery, 2022
Stepped wedge cluster randomized trials enable rigorous evaluations of health intervention programs in pragmatic settings. In the present study, we aimed to update neurosurgeon scientists on the design of stepped wedge randomized trials.We have presented an overview of recent methodological developments for stepped wedge designs and included an update ...
Fan Li, Rui Wang
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Power analysis for stepped wedge trials with multiple interventions

Statistics in Medicine, 2022
Stepped wedge design (SWD) trials are cluster randomized trials that feature staggered, unidirectional cross‐over between treatment conditions. Existing literature on power for SWDs focuses primarily on designs with two conditions, typically a control and an intervention condition. However, SWDs with more than one treatment condition are being proposed
Phillip Sundin, Catherine M. Crespi
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Variance formulae for multiphase stepped wedge cluster randomized trial

Statistics in Medicine, 2020
AbstractIn a multiphase stepped wedge cluster randomized trial (MSW‐CRT), more than one intervention will be initiated on each sequence in a fixed order. Hence, with the MSW‐CRT design, the effect of the first intervention can be evaluated when compared to control, as well as the added‐on effects of the subsequent interventions.
Pengyue Zhang, Abigail Shoben, Rebecca Jackson, Soledad Fernandez   +3 more
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Changes in Firearm and Medication Storage Practices in Homes of Youths at Risk for Suicide: Results of the SAFETY Study, a Clustered, Emergency Department-Based, Multisite, Stepped-Wedge Trial.

Annals of Emergency Medicine, 2020
STUDY OBJECTIVE We evaluate whether a counseling intervention implemented at the hospital level resulted in safer firearm and medication storage by caregivers of youths aged 10 to 17 years after their child's evaluation in the emergency department (ED ...
Matthew Miller, C. Salhi, C. Barber, D. Azrael, E. Beatriz, J. Berrigan, Sara Brandspigel, M. Betz, C. Runyan   +8 more
semanticscholar   +1 more source

Design and analysis of stepped wedge cluster randomized trials

Contemporary Clinical Trials, 2007
Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a "parallel" design (i.e.
Michael A, Hussey, James P, Hughes
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Trimodal skin health programme for childhood impetigo control in remote Western Australia (SToP): a cluster randomised, stepped-wedge trial.

The Lancet Child & Adolescent Health
BACKGROUND Skin infections affect physical health and, through stigma, social-emotional health. When untreated, they can cause life-threatening conditions.
Hannah M M Thomas, S. Enkel, M. Mullane, Tracy McRae, Timothy C. Barnett, J. Carapetis, Ray Christophers, Julianne Coffin, Rebecca Famlonga, J. Jacky, Mark Jones, Julie Marsh, Kelli McIntosh, Vicki O’Donnell, Edward Pan, Glenn Pearson, Slade Sibosado, Bec Smith, T. Snelling, Andrew Steer, S. Tong, Roz Walker, A. Whelan, Kristen White, Edie Wright, A. Bowen   +25 more
semanticscholar   +1 more source

Information Content of Cluster–Period Cells in Stepped Wedge Trials

Biometrics, 2018
Summary Stepped wedge and other multiple-period cluster randomized trials, which collect data from multiple clusters across multiple time periods, are being conducted with increasing frequency; statistical research into these designs has not kept apace.
Jessica Kasza, Andrew B. Forbes
openaire   +3 more sources

Neoadjuvant chemoradiotherapy followed by active surveillance versus standard surgery for oesophageal cancer (SANO trial): a multicentre, stepped-wedge, cluster-randomised, non-inferiority, phase 3 trial.

The Lancet Oncology
BACKGROUND A substantial proportion of individuals with oesophageal cancer have a pathological complete response after neoadjuvant chemoradiotherapy and oesophagectomy.
B. J. van der Wilk, B. Eyck, B. Wijnhoven, S. Lagarde, C. Rosman, B. Noordman, M. Valkema, Tanya M. Bisseling, P. Coene, M. V. van Det, J. Dekker, J. V. van Dieren, Michail Doukas, Stijn van Esser, W. Fiets, H. Hartgrink, J. Heisterkamp, I. Holster, B. Klarenbeek, D. van Klaveren, Eva Kouw, E. Kouwenhoven, M. Luyer, B. Mostert, G. Nieuwenhuijzen, L. Oostenbrug, J. Pierie, J. V. van Sandick, M. Sosef, M. Spaander, R. Valkema, E. S. van der Zaag, E. Steyerberg, J. V. van Lanschot, A. D. Koch, S. Nikkessen, A. van der Gaast, Q. G. de Lussanet de la Sablonière, Katharina Biermann, L. Oudijk, H. Lingsma, Roy S. Dwarkasing, J. Nuyttens, S. Gangaram-Panday, P. C. van der Sluis, G. Bulte, Peter D. Siersema, H. Westdorp, E. Aarntzen, C. V. D. van der Post, Maartje C. van Rijk, P. Braam, H. Rütten, Marcel Verheij, S. J. Zweers, Lieke Hol, E. F. C. Courrech Staal, K. Hamoen, Trudy Rapmund, E. van der Harst, Andries van der Linden, Huseyin Aktas, P. Dura, Ronald Hoekstra, A. Agool, J. van Baarlen, E. Hendriksen, H. J. Mantel, R. Quispel, S. Mulder, A. Verschoor, M. R. T. ten Broek, R. Dallinga, K. Neelis, E. de Graaf, T. D. de Wijkerslooth, M. Vollebergh, E. Owers, A. Bartels-Rutten, Liudmila L Kodach, F. Voncken, Yvonne Hilhorst, M. Warmerdam, S. Corporaal, M. Polée, Anne Marij G. van Burg, J. Nieken, Rinze Wolf, V. Oppedijk, M. Emous, D. A. Hess, W. Erkelens, S. C. S. Tromp - van Driel, M. D. Zuijdwijk, H. Doornewaard, K. Muller, P. van Duijvendijk, E. Wassenaar, W. Curvers, G. Creemers, M. Roef, Ineke van Lijnschoten, J. Nederend, M. V. D. van der Sangen, T. Budiharto, F. Heesakkers, Khalida Soufidi, Fabienne ARM Warmerdam, W. Schreurs, Bart de Vries, R. Vliegen, J. Buijsen, Ilse Stohr, Eric H. J. Belgers, J. van der Kraan, M. Slingerland, R. Raghoo, A. S. L. Crobach, A. J. van der Molen, Susan J.C.L.M. Quix, W. D. de Steur, W. Hazen, L. Beerepoot, David E. Ploeg, T. Rozema, I. Vermeltfoort, W. Jansen   +126 more
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