Results 111 to 120 of about 4,595,489 (342)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Engaging parents and carers with Sure Start New Steps [PDF]

open access: yes, 2006
This project report discusses the extent to which families in Halton are aware of the Sure Start New Steps programme. Concerns had been raised about the strategies used to inform parents and carers about Sure Start New Steps and how systematically and ...
Perry, Catherine, Samuels, Tanya
core  

Postmenopausal obesity: 12,500 steps per day as a remedy? Relationships between body composition and daily steps in postmenopausal women

open access: yes, 2014
Introduction: To verify relationships between physical activity (steps per day) and obesity (components of body composition) among postmenopausal women.
Dariusz Pośpiech   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Audit of 10,000 Steps providers

open access: yes, 2006
This report from 10,000 Steps details the findings of the recent audit of 10,000 Steps Providers. This study highlighted the Providers use of the 10,000 Steps programs and resources since the program rolled out nationally in ...
Joyner, Kelly.
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Continuing Steps to School Readiness : The Compass Report on the Evaluation of South Carolina First Steps to School Readiness

open access: yes, 2015
Compass Evaluation and Research was contracted by the SC First Steps Board of Trustees pursuant to South Carolina Section 59-125-160 to “assess the extent to which First Steps has been successful in meeting its five legislative goals and articulate the ...
South Carolina First Steps to School Readiness (Program)
core  

First Steps 4K Quarterly Report Pursuant to Proviso 1.48 and 1A.26

open access: yes, 2023
Provisos 1.48 and 1A.26 of the FY 2023-24 State Budget for South Carolina specify that: First Steps and the Department of Education must provide an equitable distribution above the minimum between public and private providers.
South Carolina First Steps to School Readiness (Program)
core  

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