Results 171 to 180 of about 13,428 (198)

Enantioselective Determination of Upadacitinib in Pharmaceutical Formulations Using Reversed‐Phase Chiral Liquid Chromatography

Journal of Separation Science, Volume 49, Issue 9, September 2026.
A reversed‐phase chiral HPLC method was developed for the enantioselective separation and quantification of upadacitinib using a Box‐Behnken design. The validated method was successfully applied to the quantification of upadacitinib in a commercial tablet formulation, and its environmental impact and practicality were evaluated using various assessment
Sakine Atila Karaca, Sona Aliyeva, Duygu Yeniceli   +2 more
wiley   +1 more source

Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates. [PDF]

Angew Chem Int Ed Engl
Wang H, Xu J, Zhou J, Gu Y.
europepmc   +1 more source

MSI: A Mahalanobis‐Based Molecular Similarity Index for High‐Dimensional Embeddings

Molecular Informatics, Volume 45, Issue 9, September 2026.
MSI pairs continuous Mol2Vec embeddings with a covariance‐aware Mahalanobis metric (dM, θM) to overcome the ranking ties and bit‐density bias of Tanimoto fingerprints. Across five reference compounds, MSI resolves more distinct neighbors than ECFP4 + Tanimoto and its geometry tracks HOMO–LUMO gaps in QM9, despite no electronic training.
Roberto Bernal‐Jaquez, Elliot Ridout‐Buhl, Emiliano Montoya, León Alday‐Toledo, Felipe Aparicio   +4 more
wiley   +1 more source

Spiro-helicenoid Carbofluoresceins: CPL-Active Emitters for Bioimaging. [PDF]

Org Lett
Erviti-Marticorena L, Simón-Fuente S, Míguez-Lago S, Paredes JM, Ribagorda M, Girón-González MD, Millán A, Cuerva JM, Miguel D.   +8 more
europepmc   +1 more source

Enantiodivergent Carbon-Phosphorus Bond Formation via Enzymatic Carbene Insertion. [PDF]

J Am Chem Soc
Carder HM, Lin EN, Roth D, Arnold FH.
europepmc   +1 more source

Single-crystal X-ray diffraction analysis and mechanistic implications of (2R*,3R*)-2-(2-phenoxyethyl)tetrahydrofuran-3-yl acetate. [PDF]

Acta Crystallogr C Struct Chem
Kelley SP, Nirpal AK, Sathyamoorthi S.
europepmc   +1 more source

Directed Heterodimerization: Total Synthesis of (-)-Folicangine, (-)-Voafolidine, (-)-Isovoafolidine, and (-)-Tabernaesine B. [PDF]

Org Lett
Raclea RC, Movassaghi M.
europepmc   +1 more source

Molecular determinants of cholesterol binding to BK channel-forming slo1 subunits. [PDF]

Arch Biochem Biophys
Schneider EH, Hawks SM, Nooh MM, Dopico AM, Bukiya AN.   +4 more
europepmc   +1 more source

Enzymatic 1,4-addition of 2-hydroxy-3-keto-glucal for β-selective aryl-<i>C</i>-glycosylation of polyphenols.

Chem Commun (Camb)
Kastner K, Pfeiffer M, Nidetzky B.
europepmc   +1 more source