Results 201 to 210 of about 36,653 (344)

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

Inhibition of phosphatidylinositol synthase and other membrane-associated enzymes by stereoisomers of hexachlorocyclohexane.

, 1985
Gregory S. Parries, Mabel Hokin-Neaverson   +1 more
openalex   +1 more source

The effects of the stereoisomers of propafenone and diprafenone in guinea‐pig heart [PDF]

, 1991
Klaus Groschner, Wolfgang Lindner, Herbert Schnedl, Walter R. Kukovetz   +3 more
openalex   +1 more source

Folate transfer in placental choriocarcinoma cells treated with valproic acid: Insights gained through comparisons with the amide derivative sec‐butylpropylacetamide and its individual stereoisomers

Epilepsia, EarlyView.
Abstract Objective We have previously shown that valproic acid (VPA) alters the expression of placental carriers of essential nutrients, including folates. Here, we exposed a placental cell line to VPA, its central nervous system‐active amide derivative sec‐butylpropylacetamide (SPD), and its individual stereoisomers to address the question of whether ...
Natalia Erenburg, Roa’a Hamed, Alina Nemirovski, Meir Bialer, Sara Eyal   +4 more
wiley   +1 more source

Phenothiazine Derivatives: The Importance of Stereoisomerism in the Tolerance and Efficacy of Antimicrobials. [PDF]

Indian J Microbiol
Ronco T, Juul M, Reynier Z, Christensen JB, Svenningsen S, Olsen RH.   +5 more
europepmc   +1 more source

Influence of fenfluramine and norfenfluramine stereoisomers on the firing rate of central monoaminergic neurons in the rat [PDF]

, 1990
Jacqueline Scuvée‐Moreau, A Dresse
openalex   +1 more source

Convegno GIF 2005 - Programma [PDF]

, 2015
Credi, Alberto
core  

EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 73, Revision 1: Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary saturated or unsaturated alicyclic alcohol, aldehyde, and esters evaluated by EFSA in FGE.12Rev2 (2011) [PDF]

, 2012
Cramer, EC, EC, EC, National Cancer Institute, SCF   +5 more
core   +1 more source

Extreme multivalency and a composite short linear motif facilitate PCNA‐binding, localisation and abundance of p21 (CDKN1A)

The FEBS Journal, EarlyView.
Regions flanking the PCNA‐binding motif in p21 contribute to high‐affinity binding through complementary charges without specific contacts. These regions affect p21 abundance, but their exact Lys/Arg composition is unimportant for PCNA binding. Conversely, both context and Lys/Arg composition of the N‐terminal flanking region are crucial for p21 ...
Signe Simonsen, Fia B. Larsen, Caroline K. Søgaard, Nicolas Jonsson, Kresten Lindorff‐Larsen, Per Bruheim, Marit Otterlei, Rasmus Hartmann‐Petersen, Birthe B. Kragelund   +8 more
wiley   +1 more source

12-Oxophytodienoate-10,11-Reductase: Occurrence of Two Isoenzymes of Different Specificity against Stereoisomers of 12-Oxophytodienoic Acid [PDF]

, 1998
Florian Schaller, Peter Hennig, Elmar W. Weiler   +2 more
openalex   +1 more source