Results 41 to 50 of about 28,782 (216)

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Abscopal Effect following Stereotactic Radiation Therapy to the Brain and Spleen in Metastatic Endometrial Cancer: A Case Report

Case Reports in Oncology
Introduction: The abscopal effect of radiation therapy is a rare phenomenon in which immune activation induces the regression of distant, nonirradiated tumors.
Yukiko Fukuda, Masahiro Kawahara, Keiko Akahane, Machi Nakagawa, Masashi Endo, Kazunari Ogawa, Michiko Nakamura, Daisuke Irie, Satoru Takahashi, Noriko Oyama-Manabe, Hiroyoshi Ko, Kenro Chikazawa, Tomoyuki Kuwata, Katsuyuki Shirai   +13 more
doaj   +1 more source

Repeated CyberKnife stereotactic body radiation therapy in hepatocellular carcinoma

Radiation Oncology, 2020
Background To explore the survival and side effects of repeated CyberKnife stereotactic body radiation therapy (CK-SBRT) on hepatocellular carcinoma patients. Methods 24 HCC patients were collected at The Fifth Medical Center of PLA General Hospital from
Jing Sun, Can Ouyang, Xiaoyun Chang, Aimin Zhang, Quan Wang, Wengang Li, Dan Zhang, Jia Wang, Dong Li, Xuezhang Duan   +9 more
doaj   +1 more source

Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer

Frontiers in Oncology, 2022
In this review we outline the current evidence for the use of hydrogel rectal spacers in the treatment paradigm for prostate cancer with external beam radiation therapy.
Michael C. Repka, Michael Creswell, Jonathan W. Lischalk, Michael Carrasquilla, Matthew Forsthoefel, Jacqueline Lee, Siyuan Lei, Nima Aghdam, Shaan Kataria, Olusola Obayomi-Davies, Brian T. Collins, Simeng Suy, Ryan A. Hankins, Sean P. Collins   +13 more
doaj   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Demystifying CyberKnife Stereotactic Body Radiation Therapy for Interventional Radiologists

The Arab Journal of Interventional Radiology, 2017
Stereotactic body radiation therapy (SBRT) using CyberKnife system is a relatively new radiation therapy that has demonstrated feasibility, safety, and efficacy with a high local control of various extracranial unresectable primary cancer and ...
Azzam Khankan, Saif Althaqfi
doaj   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Robotic stereotactic body radiation therapy for elderly medically inoperable early-stage non-small cell lung cancer

Lung Cancer: Targets and Therapy, 2013
Sana D Karam,1 Zachary D Horne,1 Robert L Hong,1,2 Nimrah Baig,1 Gregory J Gagnon,4 Don McRae,2 David Duhamel,3 Nadim M Nasr1,21Department of Radiation Oncology, Georgetown University Hospital, Washington, DC, USA; 2Department of Radiation Oncology ...
Karam SD, Horne ZD, Hong RL, Baig N, Gagnon GJ, McRae D, Duhamel D, Nasr NM   +7 more
doaj  

Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset

Clinical Pharmacology &Therapeutics, EarlyView.
Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit, Maaike van Dartel, Laura Rodwell, Hanneke van der Woude, Cornelis Boersma, Peter G. M. Mol, Doranne Hilarius   +6 more
wiley   +1 more source

Radiobiology of stereotactic body radiation therapy (SBRT) [PDF]

Reports of Practical Oncology & Radiotherapy, 2017
Recent advances in the technology of radiotherapy have enabled the development of new therapeutic modalities that deliver radiation with very high accuracy, reduced margins and high dose conformation, allowing the reduction of healthy tissue irradiated and therefore minimizing the risk of toxicity.
openaire   +2 more sources