Results 41 to 50 of about 27,810 (219)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Abscopal Effect following Stereotactic Radiation Therapy to the Brain and Spleen in Metastatic Endometrial Cancer: A Case Report

Case Reports in Oncology
Introduction: The abscopal effect of radiation therapy is a rare phenomenon in which immune activation induces the regression of distant, nonirradiated tumors.
Yukiko Fukuda, Masahiro Kawahara, Keiko Akahane, Machi Nakagawa, Masashi Endo, Kazunari Ogawa, Michiko Nakamura, Daisuke Irie, Satoru Takahashi, Noriko Oyama-Manabe, Hiroyoshi Ko, Kenro Chikazawa, Tomoyuki Kuwata, Katsuyuki Shirai   +13 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Demystifying CyberKnife Stereotactic Body Radiation Therapy for Interventional Radiologists

The Arab Journal of Interventional Radiology, 2017
Stereotactic body radiation therapy (SBRT) using CyberKnife system is a relatively new radiation therapy that has demonstrated feasibility, safety, and efficacy with a high local control of various extracranial unresectable primary cancer and ...
Azzam Khankan, Saif Althaqfi
doaj   +1 more source

Repeated CyberKnife stereotactic body radiation therapy in hepatocellular carcinoma

Radiation Oncology, 2020
Background To explore the survival and side effects of repeated CyberKnife stereotactic body radiation therapy (CK-SBRT) on hepatocellular carcinoma patients. Methods 24 HCC patients were collected at The Fifth Medical Center of PLA General Hospital from
Jing Sun, Can Ouyang, Xiaoyun Chang, Aimin Zhang, Quan Wang, Wengang Li, Dan Zhang, Jia Wang, Dong Li, Xuezhang Duan   +9 more
doaj   +1 more source

Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer

Frontiers in Oncology, 2022
In this review we outline the current evidence for the use of hydrogel rectal spacers in the treatment paradigm for prostate cancer with external beam radiation therapy.
Michael C. Repka, Michael Creswell, Jonathan W. Lischalk, Michael Carrasquilla, Matthew Forsthoefel, Jacqueline Lee, Siyuan Lei, Nima Aghdam, Shaan Kataria, Olusola Obayomi-Davies, Brian T. Collins, Simeng Suy, Ryan A. Hankins, Sean P. Collins   +13 more
doaj   +1 more source

Essential Updates 2024–2025: Surgical Strategy for Esophageal Cancer Toward a New Paradigm in the Era of Immunotherapy and Personalization

Annals of Gastroenterological Surgery, EarlyView.
This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya, Koichi Yagi, Yoshifumi Baba   +2 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Robotic stereotactic body radiation therapy for elderly medically inoperable early-stage non-small cell lung cancer

Lung Cancer: Targets and Therapy, 2013
Sana D Karam,1 Zachary D Horne,1 Robert L Hong,1,2 Nimrah Baig,1 Gregory J Gagnon,4 Don McRae,2 David Duhamel,3 Nadim M Nasr1,21Department of Radiation Oncology, Georgetown University Hospital, Washington, DC, USA; 2Department of Radiation Oncology ...
Karam SD, Horne ZD, Hong RL, Baig N, Gagnon GJ, McRae D, Duhamel D, Nasr NM   +7 more
doaj  

Radiobiology of stereotactic body radiation therapy (SBRT) [PDF]

Reports of Practical Oncology & Radiotherapy, 2017
Recent advances in the technology of radiotherapy have enabled the development of new therapeutic modalities that deliver radiation with very high accuracy, reduced margins and high dose conformation, allowing the reduction of healthy tissue irradiated and therefore minimizing the risk of toxicity.
openaire   +2 more sources