Results 81 to 90 of about 28,782 (216)

Phase II Study of Cisplatin/Gemcitabine Plus Necitumumab for Squamous NSCLC After ICI‐Platinum Therapy (WJOG14120L)

Cancer Science, EarlyView.
WJOG14120L NESSIE evaluated cisplatin, gemcitabine, and necitumumab (CGN) as second‐line therapy after ICI‐based treatment in 46 patients with advanced squamous NSCLC. ORR was 26.1%, DCR 87.0%, and median PFS 4.4 months. Although the predefined ORR threshold was not met, CGN showed modest antitumor activity with manageable toxicity.
Hiroshige Yoshioka, Keita Mori, Nobuhisa Ishikawa, Hiroaki Kanemura, Koichi Azuma, Yukihiro Toi, Hiroshi Handa, Yosuke Tamura, Hiroaki Akamatsu, Haruko Daga, Masafumi Yamaguchi, Teppei Yamaguchi, Yuki Sato, Nobuyuki Yamamoto, Kazuhiko Nakagawa, Takayasu Kurata   +15 more
wiley   +1 more source

Hypofractionated stereotactic body radiation therapy for elderly patients with stage IIB–IV nonsmall cell lung cancer who are ineligible for or refuse other treatment modalities

Lung Cancer: Targets and Therapy, 2014
Sana D Karam,1 Zachary D Horne,2 Robert L Hong,2 Don McRae,2 David Duhamel,3 Nadim M Nasr2 1Department of Radiation Oncology, University of Colorado, Denver, CO, USA; 2Department of Radiation Oncology, 3Department of Pulmonary/Critical Care Medicine ...
Karam SD, Horne ZD, Hong RL, McRae D, Duhamel D, Nasr NM   +5 more
doaj  

Case Volume and Experience in Stereotactic Radiation: Analysis of a Prospective Peer Review Program

Advances in Radiation Oncology
Purpose: Stereotactic radiation therapy (SRT) is highly effective but carries the risk of significant toxicity. We identified factors associated with SRT plans that require revision in a comprehensive, prospective peer review program conducted across a ...
Luke Peng, MD, Kee-Young Shin, MS, Tara Kosak, MEd, Ayal A. Aizer, MD, John G. Phillips, MD, MPH, Itai M. Pashtan, MD   +5 more
doaj   +1 more source

Descriptive analysis of screen‐detected versus clinically diagnosed lung cancer cases: evidence of earlier stage shift and treatment differences

Internal Medicine Journal, EarlyView.
Abstract Background Lung cancer is the leading cause of cancer‐related deaths worldwide, largely due to late‐stage diagnosis. Lung cancer screening by computed tomography (CT) reduces mortality by detecting cancers earlier in high‐risk individuals, prompting Australia to launch the National Lung Cancer Screening Program (NLCSP) in 2025.
Jazmin Guayco Sigcha, Tian Mun Chee, Ian A. Yang, Linda Passmore, Kwun M. Fong, Henry M. Marshall   +5 more
wiley   +1 more source

Improving timeliness of lung cancer care through a rapid assessment clinic

Internal Medicine Journal, EarlyView.
Abstract Background Early diagnosis and treatment of lung cancer improve survival. Guidelines from Australia and worldwide stipulate timeframes of care from referral. The Rapid Lung Assessment Clinic (RLAC) was established to fast‐track the diagnostic and treatment pathway, with a subsequent quality improvement initiative based on the initial analysis ...
Shakti V. Dabholkar, Shalini Vinod, Zinta Harrington, Benjamin Kolevski, Beth Ivimey, Joseph Descallar, Jonathan P. Williamson   +6 more
wiley   +1 more source

Survival outcomes in dogs treated with vinorelbine‐based adjuvant treatment following surgical resection of grade II and III pulmonary carcinoma

Journal of Small Animal Practice, EarlyView.
Objectives Pulmonary carcinoma in dogs is commonly managed with surgical resection; however, the role of adjuvant chemotherapy for grade II and III carcinomas remains unclear. This retrospective multicentre study investigated the outcomes in dogs treated with vinorelbine‐based adjuvant treatment (as monotherapy or combined chemotherapy) following ...
N. Wong, L. Brockley, S. Rajan, J. Yu
wiley   +1 more source

A dose‐escalated radiation protocol of 10 × 4.0 Gy provides long‐term local control in canine apocrine gland anal sac adenocarcinoma

Journal of Small Animal Practice, EarlyView.
Objectives To obtain insights for establishing radiation therapy strategies that provide long‐term locoregional benefits in canine apocrine gland anal sac adenocarcinoma, we evaluated whether a dose‐escalated protocol (10 × 4.0 Gy) could improve clinical outcomes, particularly long‐term locoregional control, while maintaining acceptable toxicity ...
M. Terauchi, Y. Fujii, R. Iwasaki, T. Mori   +3 more
wiley   +1 more source

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcoma.
Csilla Fejös, Felicitas Czichon, Maureen Griffin, Natalie Grillo, Quentin Fournier, Michelle L. Oblak, Mikaela Eng‐Toogood, Michael Kent, Isabelle Desmas‐Bazelle, Miriam Kleiter, Laura Marconato, Katie McNaught, Simona Vincenti, Carmit Chalfon, Petros Odatzoglou, Carla Rohrer Bley   +15 more
wiley   +1 more source

Pathologic Characterization and Clinical Significance of Lymphovascular Invasion in Canine Thyroid Carcinomas

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT The association between lymphovascular invasion (LVI) and outcomes in dogs with thyroid carcinoma is inadequately described, and a standardized definition of LVI is lacking. This study's objectives were to histopathologically and immunohistochemically characterize LVI and to evaluate associated clinical outcomes in dogs with thyroid carcinoma.
Maureen A. Griffin, Brianna Stoyle, Allie Oakes, Brian Flesner, Jennifer A. Lenz, Darko Stefanovski, Amy C. Durham   +6 more
wiley   +1 more source

Investigation of Radiation Isocenter Accuracy of Linear Accelerator – New Approach of Comprehensive Evaluation of Gantry, Couch, and Collimator Isocenters

Journal of Medical Physics
Objective: For stereotactic machines, recommendations demand stringent localization and precise delivery, as reflected by isocenter verification. Determining and analyzing the radiation isocenter for all clinical combinations of gantry, collimator, and ...
Avinash Kuppa Rao, Manikandan Palanisamy, G. V. Subrahmanyam, S. P. Swathi, Tamilarasan Mani   +4 more
doaj   +1 more source