Results 141 to 150 of about 41,093 (226)

An X‐ray and γ‐ray combination strategy to exploit steep dose gradients for improved prostate cancer radiotherapy: A dosimetric comparison of Taichi Pro and Halcyon

Journal of Applied Clinical Medical Physics, Volume 27, Issue 3, March 2026.
Abstract Purpose This study aimed to evaluate a novel technological platform, Taichi Pro—which integrates a 6 MV flattening filterfree linear accelerator with a 18 source Rotating Gamma System (RGS) to generate steep dose gradients via multisource focused γ‐rays and noncoplanar arcs—for precision radiotherapy in prostate cancer.
Kuo Li, Yong Yin, Ting Zhu, Weipeng Sun, Shihao Wang, Zhenjiang Li   +5 more
wiley   +1 more source

Volumetric and Linear Imaging Response After Stereotactic Radiotherapy for Vestibular Schwannoma. [PDF]

Cureus
Rocha EM, Costa PT, Arantes M, Aguiar A, Pires A, Conde S.   +5 more
europepmc   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Healthcare Resource Utilization and Cost After Temperature‐Controlled Radiofrequency Treatment of Nasal Airway Obstruction: A Real‐World Longitudinal Claims Analysis

International Forum of Allergy &Rhinology, Volume 16, Issue 3, Page 261-271, March 2026.
ABSTRACT Background Nasal airway obstruction (NAO) is prevalent with substantial health and quality of life burdens. Nasal valve collapse (NVC) is one structural cause of NAO. Temperature‐controlled radiofrequency (TCRF) nasal valve remodeling offers an alternative to invasive surgery.
David W. Kennedy, Gavin Setzen, Ashleigh A. Halderman, Kevin C. Welch, Bobby Tajudeen, Gary M. Owens, Paul J. Niklewski, Masayoshi Takashima   +7 more
wiley   +1 more source

Clinical outcomes of fractionated stereotactic radiotherapy for uveal melanoma - a Polish single-centre experience. [PDF]

Contemp Oncol (Pozn)
Deja A, Baluch P, Wróblewska-Zierhoffer M, Zwolińska E, Radomiak M, Milecki P, Rospond-Kubiak I.   +6 more
europepmc   +1 more source

Prospective Registry and Meta‐Analysis of Particle Therapy for Hepatocellular Carcinoma: Clinical Outcomes and Real‐World Impact

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background and Aims This study aimed to evaluate the clinical efficacy of particle therapy for hepatocellular carcinoma (HCC) by integrating a prospective registry and a systematic meta‐analysis. Our findings also reflect the real‐world impact of this evidence, which contributed to the national health insurance approval of particle therapy for
Masashi Mizumoto, Kei Shibuya, Kazuki Terashima, Hiromitsu Iwata, Takashi Saito, Shingo Toyama, Takashi Ogino, Masao Murakami, Tatsuya Ohno, Yoshitaka Sato, Tetsuo Akimoto, Hiroyuki Katoh, Masaru Wakatsuki, Takahiro Waki, Norio Katoh, Fuki Koizumi, Masayuki Araya, Tsuyoshi Onoe, Masaru Takagi, Tomoaki Okimoto, Hiroyuki Ogino, Haruko Numajiri, Yoshiyuki Shioyama, Takayuki Hashimoto, Hisateru Ohba, Shoji Kubo, Kiyoshi Hasegawa, Kazushi Maruo, Hidefumi Aoyama, Hideyuki Sakurai   +29 more
wiley   +1 more source

Clinical Workflow of Spine Stereotactic Radiotherapy and Radiosurgery: Insights from a Single-Institution Physics Perspective. [PDF]

Cancers (Basel)
Mackin D, Cifter G, Zlateva Y, Wang J, Ding Y, Ul Hassan MS, Wang Z, Diagaradjane P, Guan F, Salzillo TC, Krafft S, Li J, Tom MC, Ghia AJ, Briere TM.   +14 more
europepmc   +1 more source

Trastuzumab Deruxtecan‐Induced Pneumonitis: Case Series

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Three women with HER2‐positive metastatic breast cancer developed pneumonitis or interstitial lung disease after 2–9 cycles of trastuzumab deruxtecan. Presentations ranged from mild cough to CT‐confirmed ILD, often requiring corticosteroids and treatment interruption or discontinuation.
Abeer Alhuthali, Bushra Alqurashi, Yusra Banoun, Ziyad Almuylibi, Haneen Sait, Bayader Al‐Sobhi, Mohammed Alnuhait   +6 more
wiley   +1 more source