Results 41 to 50 of about 42,899 (196)

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Essential Updates 2024–2025: Surgical Strategy for Esophageal Cancer Toward a New Paradigm in the Era of Immunotherapy and Personalization

Annals of Gastroenterological Surgery, EarlyView.
This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya, Koichi Yagi, Yoshifumi Baba   +2 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Prostate Cancer Stereotactic Body Radiation Therapy with Image-guided Radiation Therapy (IGRT) Technique with Three-Dimensional Transperineal Ultrasound for IGRT Tracking of the Prostate

Brazilian Journal of Oncology
Introduction Ultrahypofractionated radical radiotherapy for prostate cancer, also known as stereotactic body radiation therapy (SBRT), is an unprecedented modality of prostate radiotherapy and is still used very sparsely in Brazil.
Igor Migowski, Arn Migowski
doaj   +1 more source

The role of stereotactic radiotherapy in the treatment of the local recurrence of colorectal cancer: A case report [PDF]

Archive of Oncology
Colorectal cancer is one of the most common malignant diseases worldwide. A multidisciplinary approach to treatment involves surgery and chemotherapy, while radiotherapy is used in the treatment of tumors localized in the pelvis.
Radosavljević Kristina, Ivanov Olivera, Bojović Marko, Ličina Jelena, Protić Mlađan, Prvulović-Bunović Nataša   +5 more
doaj   +1 more source

Clinicogenomic Features and Outcomes of Adenoid Cystic Carcinoma With Central Nervous System Metastases: A Single‐Institution Cohort Study

Head &Neck, EarlyView.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is a rare malignancy with a propensity for perineural invasion and hematogenous spread. Central nervous system (CNS) involvement is uncommon, and detailed clinical and genomic data on this aspect of the disease remain limited.
Omar Elghawy, Jack Stylli, Martin Kurian, Eitan Halper‐Stromberg, Aditi Singh, Christopher D'Avella, Lee Hartner, Roger B. Cohen   +7 more
wiley   +1 more source

Stereotactic Body Radiotherapy (SBRT) of Previously Unirradiated Mucosal Head and Neck Squamous Cell Carcinoma (SCC)

Head &Neck, EarlyView.
ABSTRACT Purpose To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in previously untreated primary mucosal head and neck cancer (HNC) patients unfit for conventional radiation therapy. Materials and Methods Retrospective analysis of previously unirradiated primary SCC mucosal HNC patients treated with SBRT from 2011 to ...
Mohammed Aldohan, Irene Karam, Amir H. Safavi, Lee Chin, Liying Zhang, Ethan Gooanratne, Madette Galapin, Antoine Eskander, Kevin Higgins, Danny Enepekides, Ian Poon   +10 more
wiley   +1 more source

High-dose stereotactic radiotherapy boost in the treatment of squamous cell carcinoma of the head and neck region

Radiation Oncology, 2022
Background Surgical resection with adjuvant concurrent radiochemotherapy is the standard of care for stage III–IV oral cavity cancer. In some cases, the dynamic course of the disease is out of the prepared schedule of treatment.
Paweł Polanowski, Agnieszka Pietruszka, Dorota Księżniak-Baran, Aleksandra Grządziel, Ewa Chmielik, Marek Kentnowski, Natalia Amrogowicz, Krzysztof Składowski, Katarzyna Polanowska   +8 more
doaj   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Stereotactic radiotherapy for patients with bone metastases: a selected group with low rate of radiation treatment during the last month of life?

Radiation Oncology
Background Complex high-precision radiotherapy, such as stereotactic body radiotherapy (SBRT), should only be offered to patients with sufficiently long survival.
Carsten Nieder, Ellinor C. Haukland, Luka Stanisavljevic, Bård Mannsåker   +3 more
doaj   +1 more source