Results 51 to 60 of about 52,263 (284)

Stereotactic body radiotherapy for oligometastases

The Lancet Oncology, 2013
The management of metastatic solid tumours has historically focused on systemic treatment given with palliative intent. However, radical surgical treatment of oligometastases is now common practice in some settings. The development of stereotactic body radiotherapy (SBRT), building on improvements in delivery achieved by intensity-modulated and image ...
Tree, A, Khoo, V, Eeles, R, Ahmed, M, Dearnaley, D, Hawkins, M, Huddart, R, Nutting, C, Ostler, P, van As, N   +9 more
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stereotactic radiotherapy for lung oligometastases

Reports of Practical Oncology and Radiotherapy, 2022
30-60% of cancer patients develop lung metastases, mostly from primary tumors in the colon-rectum, lung, head and neck area, breast and kidney. Nowadays, stereotactic radiotherapy (SRT ) is considered the ideal modality for treating pulmonary metastases.
Falcinelli, Lorenzo, Menichelli, Claudia, Casamassima, Franco, Aristei, Cynthia, Borghesi, Simona, Ingrosso, Gianluca, Draghini, Lorena, Tagliagambe, Angiolo, Badellino, Serena, di Monale e Bastia, Michela Buglione   +9 more
openaire   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Lymph Node Oligometastasis from Rectal Cancer in Contact with the Bowel Treated with High-Dose Planned Adaptive Radiotherapy [PDF]

Liaquat National Journal of Cancer Care
The efficacy of stereotactic ablative radiotherapy for oligometastases has been reported. However, there are no reports of oligometastatic lymph nodes in contact with the bowel being successfully treated with high-dose adaptive radiotherapy.
Yukihiro Hama, Etsuko Tate
doaj   +1 more source

Stereotactic radiotherapy is a useful treatment option for patients with medullary thyroid cancer

BMC Endocrine Disorders, 2021
The role of radiotherapy in advanced medullary thyroid carcinoma (MTC) is confined to patients in whom surgical treatment or the administration of tyrosine kinase inhibitors are not possible or contraindicated.
Aleksandra Kukulska, Jolanta Krajewska, Zofia Kołosza, Aleksandra Grządziel, Mateusz Gajek, Ewa Paliczka-Cieślik, Dorota Syguła, Kornelia Ficek, Aneta Kluczewska-Gałka, Barbara Jarząb   +9 more
doaj   +1 more source

Historical progress of stereotactic radiation surgery

Journal of Medical Physics, 2023
Radiosurgery and stereotactic radiotherapy have established themselves as precise and accurate areas of radiation oncology for the treatment of brain and extracranial lesions.
Navid Khaledi, Rao Khan, James L Gräfe
doaj   +1 more source

Stereotactic radiotherapy for bone oligometastases

Reports of Practical Oncology and Radiotherapy, 2022
About 60-90% of cancer patients are estimated to develop bone metastases, particularly in the spine. Bone scintigraphy, computed tomography (CT ) and magnetic resonance imaging (MRI ) are currently used to assess metastatic bone disease; positron emission tomography/computed tomography (PET-CT ) has become more widespread in clinical practice because ...
Colosimo C., Pasqualetti F., Aristei C., Borghesi S., Forte L., Mignogna M., Badii D., Bosio M., Paiar F., Nanni S., Bertocci S., Lastrucci L., Parisi S., Ingrosso G.   +13 more
openaire   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Fractionated stereotactic radiotherapy for uveal melanoma: Long‐term outcome and control rates [PDF]

, 2022
Purpose: The aim of our study is to evaluate local tumour control rates, radiation side-effects, visual preservation and disease-free survival (DFS) of uveal melanoma (UM) patients treated with fractionated stereotactic radiotherapy (fSRT).
Michael J. Bergmann, Yavuzyigitoglu, Serdar, Bergmann, M. J., Kiliç, Emine; id_orcid, van Rij, Caroline M., Baart, Sara J., Sara J. Baart, Nicole C. Naus, van Beek, Jackelien G.M., Paridaens, Dion; id_orcid, Serdar Yavuzyigitoglu, Caroline M. van Rij, Emine Kiliç, Kiliç, Emine, Paridaens, Dion, van Beek, Jackelien G. M., Dion Paridaens, Naus, Nicole C., Bergmann, Michael J., Jackelien G. M. van Beek   +19 more
core   +1 more source