Results 61 to 70 of about 226,373 (256)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Historical progress of stereotactic radiation surgery

Journal of Medical Physics, 2023
Radiosurgery and stereotactic radiotherapy have established themselves as precise and accurate areas of radiation oncology for the treatment of brain and extracranial lesions.
Navid Khaledi, Rao Khan, James L Gräfe
doaj   +1 more source

Fractionated stereotactic radiotherapy for uveal melanoma: Long‐term outcome and control rates [PDF]

, 2022
Purpose: The aim of our study is to evaluate local tumour control rates, radiation side-effects, visual preservation and disease-free survival (DFS) of uveal melanoma (UM) patients treated with fractionated stereotactic radiotherapy (fSRT).
Michael J. Bergmann, Yavuzyigitoglu, Serdar, Bergmann, M. J., Kiliç, Emine; id_orcid, van Rij, Caroline M., Baart, Sara J., Sara J. Baart, Nicole C. Naus, van Beek, Jackelien G.M., Paridaens, Dion; id_orcid, Serdar Yavuzyigitoglu, Caroline M. van Rij, Emine Kiliç, Kiliç, Emine, Paridaens, Dion, van Beek, Jackelien G. M., Dion Paridaens, Naus, Nicole C., Bergmann, Michael J., Jackelien G. M. van Beek   +19 more
core   +2 more sources

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Implementation of Stereotactic Surgery and Radiotherapy Top-Up Policy in National Health Insurance

Jurnal Jaminan Kesehatan Nasional
BPJS Kesehatan administers Indonesia’s social security program in health and ensures access to quality and affordable healthcare services. Radiotherapy is one of the cancer services covered under the Jaminan Kesehatan Nasional program, with total ...
Mirzal Fuadi Mirzal Fuadi, Fandy Khairuzka, Widi Utami, Anggaraningsih WDC, Andi Ashar, Reza Shahristanto   +5 more
doaj   +1 more source

Lymph Node Oligometastasis from Rectal Cancer in Contact with the Bowel Treated with High-Dose Planned Adaptive Radiotherapy [PDF]

Liaquat National Journal of Cancer Care
The efficacy of stereotactic ablative radiotherapy for oligometastases has been reported. However, there are no reports of oligometastatic lymph nodes in contact with the bowel being successfully treated with high-dose adaptive radiotherapy.
Yukihiro Hama, Etsuko Tate
doaj   +1 more source

Integrating stereotactic radiotherapy and systemic therapies

, 2022
: This paper focuses on stereotactic radiotherapy (SRT ) interactions with targeted therapies and immune system modulating agents because SRT inevitably interacts with them in the treatment of oligometastatic patients.
Gonnelli A., Borghesi S., Delishaj D., Belgioia L., Palumbo I., Aristei C., Arcangeli S., Pirtoli L., Pasqualetti F.   +8 more
core   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Radiotherapy Modality and Primary Tumor Type as Determinants of Outcomes in Brain Metastases: A Retrospective Study of 734 Patients

Medicina
Background and Objectives: Radiotherapy (RT) is a standard component of palliative treatment for brain metastases. The aim of this retrospective analysis of consecutive patients treated between 2017 and 2023 is to analyze overall survival after brain ...
Lucie Hnidakova, Andrea Pagacova, Sarka Kristkova, Jan Svancara, Ludmila Hynkova, Petr Pospisil, Renata Belanova, Jana Maistryszinova, Radek Lakomy, Tomas Prochazka, Miroslav Vrzal, Jiri Sana, Radim Jancalek, Martin Smrcka, Ivana Kolouskova, Lukas Moran, Katerina Prochazkova, Vera Andraskova, Jan Garcic, Pavel Slampa, Pavel Fadrus, Tomas Kazda   +21 more
doaj   +1 more source