Results 151 to 160 of about 265,264 (294)
Assessing the risk of central post-stroke pain of thalamic origin by lesion mapping [PDF]
, 2017 Central post-stroke pain of thalamic origin is an extremely distressing and often refractory disorder. There are no well-established predictors for pain development after thalamic stroke, and the role of different thalamic nuclei is unclear.
Andreou, Anna P. +9 more
core
Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging
Aging Cell, EarlyView.Hevin/Sparcl‐1 is a synaptogenic protein secreted by astrocytes. We used adeno‐associated virus (AAV) to increase its expression in hippocampal astrocytes of APP/PSEN1 mice, an animal model for Alzheimer's disease (AD). This procedure improved cognitive performance both in the AD model and in middle‐aged wild‐type animals.
Felipe Cabral‐Miranda +3 more
wiley +1 more source
Aging Cell, EarlyView.The effect of advancing age and intraocular pressure injury on retinal ganglion cell function and synaptic connectivity. While young mice modulate their synaptic input to recover retinal ganglion cell function following injury, older mice compensate by altering their action potential threshold and axon initial segment (AIS) length to increase intrinsic
Vicki Chrysostomou +9 more
wiley +1 more source
A low-cost technique to cryo-protect and freeze rodent brains, precisely aligned to stereotaxic coordinates for whole-brain cryosectioning [PDF]
, 2013 Vadim Pinskiy +5 more
openalex +1 more source
Aging Cell, EarlyView.Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik +20 more
wiley +1 more source
Stereotaxic surgery in the treatment of brain tumors
Acta Médica del Centro, 2014 In recent years Neurosurgery Specialists have seen a dramatic improvement in imaging techniques, which has led, in parallel, to the resurgence of stereotactic techniques.
Juan Guillermo Trigo Naranjo +1 more
doaj
Brain Pathology, EarlyView.(A) PPN‐cholinergic neurons degenerate during PD. We stereologically counted their rostro‐caudal distribution in post‐mortem PPNs in health versus PD. (Bi) Serial PPN‐containing samples were cholinergic antibody‐DAB stained. (Bii) Only DAB‐stained neurons on green lines and inside the box were counted.
Puneet Kumar Sharma +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin +6 more
wiley +1 more source
Bosutinib mitigates inflammation in experimental sepsis
European Journal of Clinical Investigation, EarlyView.Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha +14 more
wiley +1 more source
Evaluating techniques in tissue clarification using CLARITY imaging and investigating where sodium is sensed in the body [PDF]
, 2016 OBJECTIVE: Previous studies have shown the significant contribution of sympathoinhibition in response to sodium loading to prevent increases in mean arterial blood pressure in salt resistant phenotypes.
Neal, Christopher Matthew
core +1 more source