Results 171 to 180 of about 9,592,818 (278)

Modulation of the Neurovascular Unit by the Locus Coeruleus-Norepinephrine System: From Physiological Mechanisms to Therapeutic Applications. [PDF]

FASEB J
Pan Z, Jia Z, Jiang T, Cai Q, Di Z, Gan L, Ma C, Lin X.   +7 more
europepmc   +1 more source

Interoceptive Information of Physical Vigor Through Circulating Insulin‐Like Growth Factor 1

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
Schematic representation of the relationships between circulating IGF‐1, orexin, and VTA neurons to promote physical activity. After physical activity is increased in response to internal or external stimuli, entrance of circulating IGF‐1 into the brain is enhanced (1).
Jonathan A. Zegarra‐Valdivia, M. Zahid Khan, Jansen Fernandes, Kentaro Suda, M. Estrella Fernandez de Sevilla, Sonia Díaz‐Pacheco, Ignacio Torres Aleman   +6 more
wiley   +1 more source

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment. [PDF]

Nat Aging
Remesal L, Sucharov-Costa J, Wu Y, Pratt KJB, Bieri G, Philp A, Philp A, Phan M, Aghayev T, White CW, Wheatley EG, Zou B, Desousa BR, Couthouis J, Jian IH, Xie XS, Lu Y, Maynard JC, Burlingame AL, Villeda SA.   +19 more
europepmc   +1 more source

Comparing Functional Consequences of Human iPSC‐Microglia and Neural Stem Cell‐Derived Extracellular Vesicles in Mitigating Cognitive Decline in Alzheimer's Disease

Aging Cell, Volume 25, Issue 1, January 2026.
Systemic (retro‐orbital vein) recurrent injections of human iPSC‐microglia and neural stem cell‐derived extracellular vesicles in a 5xFAD mouse model of Alzheimer's disease significantly improve cortex‐dependent cognitive function, reduce amyloid beta plaques, mitigate microglial and astrocytic activation, deliver neuroprotective miRNA cargo, and ...
Robert P. Krattli Jr., Mineh Markarian, Shreya Madan, Devyani Swami, Amanda McQuade, Janet E. Baulch, Matthew Blurton‐Jones, Munjal M. Acharya   +7 more
wiley   +1 more source

A brief guide for gene delivery to the brain using adeno-associated viral vectors. [PDF]

Mol Cells
Han S, Yang EM, Hur EM.
europepmc   +1 more source

Comparison of automated and manual approaches for microglial quantification and classification: A focus on the HALO digital pathology platform

Brain Pathology, Volume 36, Issue 1, January 2026.
The Halo microglial activation module has not been formally validated in the literature. Comparison of this module with established methods revealed varied performance dependent on tissue thickness, highlighting the need for care to be taken when optimising image analysis parameters. Abstract Phenotypic changes in microglia have been linked to multiple
Laura M. Carr, Bianca Guglietti, Ing Chee Wee, Ian F. Musgrave, Sanam Mustafa, Frances Corrigan, Lyndsey E. Collins‐Praino   +6 more
wiley   +1 more source

The Optically Guided and Pre-assembled Implantation Cranial Window Reveals Cortical Spatial Representations during Navigation. [PDF]

Research (Wash D C)
Zhao W, Gao L, Wu Y, Xiao G, Li A, Wang M, Liu H, Yang J, Jin D, Zhang Y, Yuan Y, Dai P.   +11 more
europepmc   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, Volume 183, Issue 1, Page 171-188, January 2026.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

Selective Detection of Acetylcholine against Choline and In Vivo Measurement in the Mouse Brain Using the Micropipet-Supported Liquid/Liquid Interface Electrode. [PDF]

ACS Meas Sci Au
Xu P, Shen M.
europepmc   +1 more source

Electrical Synapses Contribute to Sleep‐Dependent Declarative Memory Retention

European Journal of Neuroscience, Volume 63, Issue 2, January 2026.
Blocking electrical synapses (gap junctions) in healthy humans by mefloquine impaired the sleep‐dependent retention of verbal declarative memory and improved sensorimotor memory consolidation irrespective of sleep. Mefloquine also disrupted the coupling of sleep spindles to EEG slow oscillations in humans but did not affect hippocampal sharp‐wave ...
Gordon B. Feld, Niels Niethard, Jianfeng Liu, Sandra Gebhardt, Lisa Kleist, Kerstin Brugger, Andreas Fritsche, Jan Born, Hong‐Viet V. Ngo, Manfred Hallschmid   +9 more
wiley   +1 more source