Results 191 to 200 of about 145,232 (261)

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Sterically Controlled Interfacial Charge-Transfer Mechanisms in Unsymmetrical Squaraine Dyes for Suppressed Aggregation and Enhanced Performance in High-Efficiency Dye-Sensitized Solar Cells. [PDF]

ChemistryOpen
Alotaibi AN, Al-Horaibi SA, Almulaiky YQ, Arabie A.   +3 more
europepmc   +1 more source

Isosteric Substitution Enables Rational Design of Two‐Dimensional Energetic Crystals

Advanced Science, EarlyView.
Isosteric substitution transforms a classical nitro–amine motif into two‐dimensional aminofurazans with performance beyond TATB. ABSTRACT Two‐dimensional (2D) energetic crystals dissipate mechanical insult via interlayer slip, yet their molecular design space remains narrow.
Linyuan Wen, Wentong Tu, Tao Yu, Chao Chen, Zhixiang Zhang, Zhixiang Xie, Yingzhe Liu   +6 more
wiley   +1 more source

Cudratricusxanthone A Exhibits Antitumor Activities Against NSCLC Harboring EGFR L792H and G796R Triple Mutations via Regulating EGFR-ERK/AKT/STAT3 Signaling. [PDF]

Molecules
Wang Y, Xian J, Wang Z, Wang J, Zhang R, Sheng J, Wang J, Sun P.   +7 more
europepmc   +1 more source

Cis-Acting Chaperoning by Macromolecular Tethering: A Built-In Layer of Cellular Chaperoning. [PDF]

Int J Mol Sci
Choi SI, Jin Y, Choi Y, Seong BL.
europepmc   +1 more source

Outer-surface charge modulation of photothermal diffusion voltage enables ultrasensitive sensing in nanofluidic membranes. [PDF]

Chem Sci
Ma Y, Yang X, Qi B, Yang X, He Z, Feng N, Dai L, Zhang A, Huang Y, Xia F.   +9 more
europepmc   +1 more source

A Negatively Curved Pyrene-Fused Azaacene. [PDF]

Angew Chem Int Ed Engl
Carini M, Martín-Arroyo M, Melle-Franco M, Mateo-Alonso A.   +3 more
europepmc   +1 more source

Heparan sulfate promotes autoactivation of procathepsin K by destabilizing the propeptide-catalytic domain interaction. [PDF]

Biochem J
Hao H, Zhang X, Liu J, Xu D.
europepmc   +1 more source

Minimum effort, maximum effect: modulating twisted intramolecular charge transfer for ultralong room temperature phosphorescence. [PDF]

Chem Sci
Guo WJ, Yan S, Xu S, Qi T, Peng HQ.
europepmc   +1 more source