Results 81 to 90 of about 127,504 (265)

Anti-cooperative Self-Assembly with Maintained Emission Regulated by Conformational and Steric Effects. [PDF]

Angew Chem Int Ed Engl, 2022
Helmers I, Hossain MS, Bäumer N, Wesarg P, Soberats B, Shimizu LS, Fernández G.   +6 more
europepmc   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Steric and Electronic Effects in the Enzymatic Catalysis of Choline-TMA Lyase

Biomolecules
An important microbial enzymatic pathway in the gut is choline/phosphatidylcholine degradation in which intestinal microbes utilize dietary choline to produce TMA via the choline utilization cluster polypeptide C (CutC) enzyme, a member of the glycyl ...
Valentin Gogonea, Stanley L. Hazen
doaj   +1 more source

Steric Effects on the Chelation of Mn²⁺ and Zn²⁺ by Hexadentate Polyimidazole Ligands: Modeling Metal Binding by Calprotectin Site 2. [PDF]

Chemistry, 2023
Gaynor RB, McIntyre BN, Lindsey SL, Clavo KA, Shy WE, Mees DE, Mu G, Donnadieu B, Creutz SE.   +8 more
europepmc   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

PolyGraph – Flexible, Biocompatible & Electrically Optimized Graphene‐Polymer Composites for Next‐Generation Neural Interfaces

Advanced Healthcare Materials, EarlyView.
PolyGraph, a flexible graphene‐polycaprolactone nanocomposite, unites conductivity, biocompatibility, and processability for next‐generation neural interfaces. Fabricated into microneedle arrays with ultra‐flexible backings, PolyGraph enables bidirectional neuronal recording and stimulation in brain tissue, advancing brain‐computer interface (BCI) and ...
Jack Maughan, Ian Woods, Cian O'Connor, Pablo Quintana‐Sarti, Eoin Caffrey, Jose M. Munuera, Tian Carey, Adrian Dervan, Alejandro López Valdés, Omar Mamad, Maeve A. Caldwell, Fergal J. O'Brien, Jonathan N. Coleman   +12 more
wiley   +1 more source

Steric Effects in the Deposition Mode and Drug-Delivering Efficiency of Nanocapsule-Based Multilayer Films. [PDF]

ACS Omega, 2022
Xu L, Chu Z, Zhang J, Cai T, Zhang X, Li Y, Wang H, Shen X, Cai R, Shi H, Zhu C, Pan J, Pan D.   +12 more
europepmc   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, EarlyView.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source

Steric and hydrophilic/hydrophobic effects of organic cations on electrochemical CO reduction

Nature Communications
The identity of cations plays a critical role in electrochemical CO2 and CO reduction reactions. While most research has focused on elucidating the effects of alkali metal cations, the influence of organic cations, which are widely employed in practical ...
Liwei Xue, Fengyuan Wei, Jieyu Wang, Xuelin Huang, Huijuan Wang, Guangzhe Wang, Li Xiao, Gongwei Wang, Lin Zhuang   +8 more
doaj   +1 more source