Results 51 to 60 of about 254,410 (141)

Balancing inflammation: the specific roles of serum amyloid A proteins in sterile and infectious diseases

Frontiers in Immunology
Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile ...
Tirthankar Mohanty, Katarina Miličević, Henri Göthert, Andreas Tillmann, Médea Padra, Praveen Papareddy, Heiko Herwald   +6 more
doaj   +1 more source

Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions

Cell Reports, 2014
Hyporesponsiveness by phagocytes is a well-known phenomenon in sepsis that is frequently induced by low-dose endotoxin stimulation of Toll-like receptor 4 (TLR4) but can also be found under sterile inflammatory conditions.
Judith Austermann, Judith Friesenhagen, Selina Kathleen Fassl, Theresa Ortkras, Johanna Burgmann, Katarzyna Barczyk-Kahlert, Eugen Faist, Siegfried Zedler, Sabine Pirr, Christian Rohde, Carsten Müller-Tidow, Maren von Köckritz-Blickwede, Constantin S. von Kaisenberg, Stefanie B. Flohé, Thomas Ulas, Joachim L. Schultze, Johannes Roth, Thomas Vogl, Dorothee Viemann   +18 more
doaj   +1 more source

Emerging roles of Toll-like receptor 9 in cardiometabolic disorders

Inflammation and Regeneration, 2020
Growing evidence suggests that damage-associated molecule patterns (DAMPs) and their receptors, pattern recognition receptors (PRRs), are associated with the progression of cardiometabolic disorders, including obesity-related insulin resistance and ...
Sachiko Nishimoto, Daiju Fukuda, Masataka Sata   +2 more
doaj   +1 more source

Bilateral Sterile Intraocular Inflammation Following Intravitreal Aflibercept 8 mg Injections: A Case Report

Reports
Background and Clinical Significance: To report a case of bilateral sterile intraocular inflammation following intravitreal aflibercept 8 mg (Eylea HD) injections.
Ram Cohen, Tomer Kerman, Omer Trivizki
doaj   +1 more source

PKR modulates sterile systemic inflammation-triggered neuroinflammation and brain glucose metabolism disturbances

Frontiers in Immunology
Sterile systemic inflammation may contribute to neuroinflammation and accelerate the progression of neurodegenerative diseases. The double-stranded RNA-dependent protein kinase (PKR) is a key signaling molecule that regulates immune responses by ...
Wai-Yin Cheng, Wai-Yin Cheng, Wai-Yin Cheng, Xin-Zin Lee, Michael Siu-Lun Lai, Yuen-Shan Ho, Raymond Chuen-Chung Chang, Raymond Chuen-Chung Chang   +7 more
doaj   +1 more source

The sensitivity and specificity of 99mTc-IgG radiotracer to differentiate infection lesions induced by Staphylococcus aureus and sterile inflammation lesions induced by carrageenan assay in rat’s foot

Electronic Physician, 2018
Background: Detection and identification of infection from sterile inflammation foci has a crucial role in diagnosis and therapy of patients in clinical practice.
Saeed Heidari Kaydan, Alireza Doroudi, Faramarz Ahmadi, Mohammad Javad Khodayar, Mostafa Erfani   +4 more
doaj   +1 more source

Preventing Peritoneal Dialysis-Associated Fibrosis by Therapeutic Blunting of Peritoneal Toll-Like Receptor Activity

Frontiers in Physiology, 2018
Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure. PD therapy is limited by peritoneal inflammation, which leads to peritoneal membrane failure as a result of progressive fibrosis.
Anne-Catherine Raby, Mario O. Labéta
doaj   +1 more source

Sterile Intraocular Inflammation Associated With Faricimab

JAMA Ophthalmology
ImportanceRandomized clinical trials are conducted to establish both drug safety and efficacy. However, evidence of adverse events associated with these drugs in the clinical practice setting can be of value at generating hypotheses regarding less common safety issues, even if causality cannot be determined.ObjectiveTo present and analyze cases of ...
Cozzi, Mariano, Ziegler, Alexander, Fasler, Katrin, Muth, Daniel Rudolf, Blaser, Frank, Zweifel, Sandrine Anne   +5 more
openaire   +3 more sources

High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation

Frontiers in Immunology, 2018
High-mobility group box 1 (HMGB1), a well-known danger-associated molecular pattern molecule, acts as a pro-inflammatory molecule when secreted by activated immune cells or released after necrotic cell damage.
Sook Young Kim, Myoungsun Son, Sang Eun Lee, In Ho Park, In Ho Park, Man Sup Kwak, Myeonggil Han, Hyun Sook Lee, Eun Sook Kim, Jae-Young Kim, Jong Eun Lee, Ji Eun Choi, Betty Diamond, Jeon-Soo Shin, Jeon-Soo Shin, Jeon-Soo Shin   +15 more
doaj   +1 more source

Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts

Cell Reports
Summary: Triggering receptor expressed on myeloid cells 1 (TREM-1) has been shown to amplify inflammatory signals, such as Toll-like receptor signaling, after infection and sterile injury.
Yuriko Terada, Wenjun Li, Junedh M. Amrute, Amit I. Bery, Charles R. Liu, Venkatrao Nunna, Christian Corbin Frye, Hao Dun, Andrew L. Koenig, Hannah P. Luehmann, Gyu Seong Heo, Macee C. Owen, Alexander N. Wein, Yongjian Liu, Jon H. Ritter, Sumanth D. Prabhu, Ruben G. Nava, Andrew E. Gelman, Marina Cella, Marco Colonna, Kory J. Lavine, Daniel Kreisel   +21 more
doaj   +1 more source