Results 81 to 90 of about 351,681 (398)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Association between relative fat mass and sterility in women of reproductive age in the United States: results from the 2013–2018 NHANES

Frontiers in Endocrinology
BackgroundA major problem that affects women of reproductive age globally is sterility. A new statistic called Relative Fat Mass (RFM) provides an accurate representation of the percentage of total body fat in people.
Mengmeng Sun, Mengmeng Sun, Yuxing Lu, Yuxing Lu, Xi Yang, Xiaogang Mao, Xiaogang Mao   +6 more
doaj   +1 more source

Alteration of Neural Stem Cell Functions in Ataxia and Male Sterility Mice: A Possible Role of β-Tubulin Glutamylation in Neurodegeneration [PDF]

, 2021
Abdullah Md. Sheikh, Shozo Yano, Shatera Tabassum, Koji Omura, Asuka Araki, Shingo Mitaki, Yoshie Ito, Shuai Huang, Atsushi Nagai   +8 more
openalex   +1 more source

Plant Mitochondrial Genome Evolution and Cytoplasmic Male Sterility

, 2017
Mitochondria are responsible for providing energy currency to life processes in the molecular form of ATP and are therefore typically referred to as the power factories of cells.
Zhiwen Chen, Nan Zhao, Shuang-shuang Li, C. Grover, Hushuai Nie, J. Wendel, J. Hua   +6 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mitochondrial genetics of alloplasmic male-sterile Brassica napus lines [PDF]

, 2005
Reliable and economical production of hybrid (F1) varieties requires efficient means to control pollination. The predominant system for pollination control of most field crops today is cytoplasmic male sterility (CMS).
Leino, Matti
core  

Sterilization Modality Selection: Role of Sterility Assurance Subject Matter Expert [PDF]

, 2021
Jami McLaren, Joyce M. Hansen, Vu Le
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The physical, chemical, and microbiological stability of chloramphenicol ophthalmic solution

Libyan International Medical University Journal, 2018
Aims: The aim of this work is to “predict” the remaining shelf-life of chloramphenicol (CH) eye drops, commercially marketed, using the theoretical “Longland–Rowbotham model,”” followed by confirmation of findings by practical means.
Tauwfik Salih, Idris El-Mahdi
doaj   +1 more source

Characterization of an allotriploid strawberry Fragaria × bifera Duchesne (Rosaceae) from Europe [PDF]

, 2015
Peer ...
Gerstberger, Pedro, Nosrati, Houshang, Price, Adam H., Wilcock, Chris C.   +3 more
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